针刺促进脊髓损伤后神经功能恢复的机制及相关信号通路的作用

doi:10.3969/j.issn.1006-9771.2017.06.004

《中国康复理论与实践》 ›› 2017, Vol. 23 ›› Issue (6): 641-644.doi: 10.3969/j.issn.1006-9771.2017.06.004

针刺促进脊髓损伤后神经功能恢复的机制及相关信号通路的作用

李华南¹, 张海明¹, 顾兵², 原琴琴², 闵友江¹

1.江西中医药大学附属医院创伤骨科,江西南昌市 330006;
2.江西科技师范大学药学院,江西南昌市 330013。

收稿日期:2016-11-21 修回日期:2017-01-11 出版日期:2017-06-25 发布日期:2017-06-27
作者简介:李华南(1974-),女,汉族,江西南昌市人,博士,主任中医师,副教授,主要研究方向：中医骨伤临床、教学及科研。E-mai: bguemory@msn.com。
基金资助:
1.国家自然科学基金项目(No.30960448; No.81360562); 2.江西省自然科学基金项目(No.20142BAB205023)

Mechanism of Acupuncture for Recovery of Neurological Function after Spinal Cord Injury and Role of Related Signal Pathway (review)

LI Hua-nan¹, ZHANG Hai-ming¹, GU Bing², YUAN Qin-qin², MIN You-jiang¹

1. Department of Trauma Orthopedics, the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330006, China;
2. School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi 330013, China;

Received:2016-11-21 Revised:2017-01-11 Published:2017-06-25 Online:2017-06-27
Contact: Correspondence to LI Hua-nan. E-mail: bguemory@msn.com

摘要/Abstract

摘要： 本文介绍针刺促进脊髓损伤后神经功能恢复的主要生物学机制,包括抑制炎症反应和氧化应激,减轻神经病理性疼痛,增加神经营养活性物质,调节细胞生存/凋亡基因和神经再生信号通路。

关键词: 脊髓损伤, 针刺, 神经功能, 氧化应激, 神经病理性疼痛, 凋亡, 信号通路, 综述

Abstract: This article introduced the main biological mechanisms of acupuncture promoting nerve function recovery after spinal cord injury, which include inhibition of inflammation and oxidative stress, alleviation of neuropathic pain, increase of neurotrophic active substance, regulation of cell survival/apoptosis gene and neural regeneration pathway.

Key words: spinal cord injury, acupuncture, nerve function, oxidative stress, neuropathic pain, apoptosis, signal pathway, review

中图分类号:

R651.2

李华南, 张海明, 顾兵, 原琴琴, 闵友江. 针刺促进脊髓损伤后神经功能恢复的机制及相关信号通路的作用[J]. 《中国康复理论与实践》, 2017, 23(6): 641-644.

LI Hua-nan, ZHANG Hai-ming, GU Bing, YUAN Qin-qin, MIN You-jiang. Mechanism of Acupuncture for Recovery of Neurological Function after Spinal Cord Injury and Role of Related Signal Pathway (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(6): 641-644.

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针刺促进脊髓损伤后神经功能恢复的机制及相关信号通路的作用

Mechanism of Acupuncture for Recovery of Neurological Function after Spinal Cord Injury and Role of Related Signal Pathway (review)

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