神经血管单元与神经退行性疾病关系研究进展

doi:10.3969/j.issn.1006-9771.2018.03.007

Abstract

Abstract: The concept of neurovascular units studies the interaction between neural cells and blood vessels, regards the blood-brain barrier as the core, and relates with the neurodegenerative diseases. This paper reviewed the relationship between neurovascular units and neurodegenerative diseases, such as Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, multiple sclerosis, etc.

Key words: neurovascular unit, blood-brain barrier, neurodegenerative disease, review

CLC Number:

R741

LI Jia-shuai, ZHU Lu-wen, YE Tao, LI Hong-yu, LIANG Bi-ying, TANG Qiang. Relationship of Neurovascular Units and Neurodegenerative Diseases (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(3): 287-289.

References

[1] 薛小燕,郭小华,李敏,等. 神经退行性疾病发病机制研究进展[J]. 中国老年学杂志, 2015, 35(11): 3149-3152.
[2] 张宁,李韶菁,余红,等. 神经血管单元信号通路机制研究进展[J]. 中国新药杂志, 2012, 21(14): 1621-1626.
[3] Sá-Pereira I, Brites D, Brito MA.Neurovascular unit: a focus on pericytes[J]. Mol Neurobiol, 2012, 45(2): 327-347.
[4] Winkler EA, Bell RD, Zlokovic BV.Central nervous system pericytes in health and disease[J]. Nat Neurosci, 2011, 14(11): 1398-1405.
[5] 许兵,张俞,杜久林. 血脑屏障的研究进展[J]. 生理学报, 2016, 68(3): 306-322.
[6] Fricker G.Drug transport across the blood-brain barrier[J]. Pharm Weekbl Sci, 1992, 14(5): 305-310.
[7] Farrington GK, Caram-Salas N, Haqqani AS, et al.A novel platform for engineering blood-brain barrier-crossing bispecific biologics[J]. FASEB J, 2014, 28(11): 4764-4778.
[8] Prades R, Ollersalvia B, Schwarzmaier SM, et al.Applying the retro-enantio approach to obtain a peptide capable of overcoming the blood-brain barrier[J]. Angew Chem Int Ed Engl, 2015, 54(13): 3967-3972.
[9] Lajoie JM, Shusta EV.Targeting receptor-mediated transport for delivery of biologics across the blood-brain barrier[J]. Annu Rev Pharmacol Toxicol, 2015, 55(1): 613-631.
[10] Parrish KE, Sarkaria JN, Elmquist WF.Improving drug delivery to primary and metastatic brain tumors: Strategies to overcome the blood-brain barrier[J]. Clin Pharmacol Ther, 2015, 97(4): 336-346.
[11] Hawkins BT, Davis TP.The blood-brain barrier/neurovascular unit in health and disease[J]. Pharmacol Rev, 2005, 57(2): 173-185.
[12] Hamel E.Perivascular nerves and the regulation of cerebrovascular tone[J]. J Appl Physiol (1985), 2006, 100(3): 1059-1064.
[13] 唐强,葛腾,朱路文. 脑缺血后神经血管单元保护的研究进展[J]. 中国康复医学杂志, 2014, 29(10): 991-994.
[14] Benarroch EE.Neurovascular unit dysfunction: a vascular component of Alzheimer disease?[J]. Neurology, 2008, 70(3): 243-244.
[15] Xing C, Hayakawa K, Lok J, et al.Injury and repair in the neurovascular unit[J]. Neurol Res, 2012, 34(4): 325-330.
[16] Zlokovic BV.The blood-brain barrier in health and chronic neurodegenerative disorders[J]. Neuron, 2008, 57(2): 178-201.
[17] 齐志刚,李坤成,王军. 为更早识别阿尔茨海默病:阿尔茨海默病神经影像学计划简介[J]. 中国现代神经疾病杂志, 2014, 14(4): 277-280.
[18] 张贺奡,庆宏. 阿尔茨海默症发病机制及治疗方法研究进展[J]. 科技导报, 2017, 35(10): 52-63.
[19] 胡谦锋,周春祥,于蓓蓓. 中药调控血脑屏障对Aβ的转运[J]. 世界科学技术-中医药现代化, 2015, 17(9): 1906-1910.
[20] Grammas P.Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease[J]. J Neuroinflammation, 2011, 8: 26.
[21] Altman R, Rutledge JC.The vascular contribution to Alzheimer's disease[J]. Clin Sci (Lond), 2010, 119(10): 407-421.
[22] Bowman GL, Kaye JA, Moore M, et al.Blood-brain barrier impairment in Alzheimer disease: Stability and functional significance[J]. Neurology, 2007, 68(21): 1809-1814.
[23] Bell RD, Zlokovic BV.Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease[J]. Acta Neuropathol, 2009, 118(1): 103-113.
[24] Bruijn LI, Miller TM, Cleveland DW.Unraveling the mechanisms involved in motor neuron degeneration in ALS[J]. Annu Rev Neurosci, 2004, 27: 723-749.
[25] Garbuzova-Davis S, Haller E, Saporta S, et al.Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS[J]. Brain Res, 2007, 1157(1): 126-137.
[26] Garbuzovadavis S, Saporta S, Sanberg PR.Implications of blood-brain barrier disruption in ALS[J]. Amyotroph Lateral Scler, 2008, 9(6): 375-376.
[27] Zhong Z, Deane R, Ali Z, et al.ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration[J]. Nat Neurosci, 2008, 11(4): 420-422.
[28] Garbuzova-Davis S, Rodrigues MCO, Hernandez-Ontiveros DG, et al.Amyotrophic lateral sclerosis: A neurovascular disease[J]. Brain Res, 2011, 1398(5): 113-125.
[29] Vangilder RL, Rosen CL, Barr TL, et al.Targeting the neurovascular unit for treatment of neurological disorders[J]. Pharmacol Ther, 2011, 130(3): 239-247.
[30] 王卫娇,田丹珂. 王宝亮教授治疗亨廷顿舞蹈病1例[J]. 中医研究, 2016, 29(6): 43-44.
[31] Drouin-Ouellet J, Sawiak SJ, Cisbani G, et al.Cerebrovascular and blood-brain barrier impairments in Huntington's disease: potential implications for its pathophysiology[J]. Ann Neurol, 2015, 78(2): 160-177.
[32] Zlokovic BV.Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders[J]. Nat Rev Neurosci, 2011, 12(12): 723-738.
[33] Stamour I, Aubé B, Rieux M, et al.Targeting cerebrovascular impairments in Huntington's disease: a novel treatment perspective[J]. Neurodegener Dis Manag, 2015, 5(5): 389-393.
[34] Huang WJ, Chen WW, Zhang X.Multiple sclerosis: pathology, diagnosis and treatments[J]. Exp Ther Med, 2017, 13(6): 3163-3166.
[35] 彭真,张礼标,吴洁,等. 多发性硬化动物模型研究进展[J]. 动物医学进展, 2017, 38(4): 108-112.
[36] Naegele M, Martin R.The good and the bad of neuroinflammation in multiple sclerosis[J]. Handb Clin Neurol, 2014, 122(3): 59-87.
[37] 王启荣,卢祖能,毛春,等. T细胞亚群与多发性硬化发病机制的关系[J]. 医学综述, 2017, 23(15): 2918-2922.

Relationship of Neurovascular Units and Neurodegenerative Diseases (review)

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