儿茶酚胺氧位甲基转移酶基因Val158Met多态性与帕金森病抑郁的相关性

doi:10.3969/j.issn.1006-9771.2018.07.001

Abstract

Abstract: Objective To explore the relationship between the polymorphism of catechol-O-methyltransferase (COMT) gene Val158Met site and depression in Parkinson's disease. Methods From June, 2016 to December, 2017, a cohort of 268 Chinese patients with Parkinson's disease and 252 age- and gender-matched healthy control subjects were recruited. The patients were divided into depression group (n=116) and non-depression group (n=152) according to Hamilton Depression Scale score. Their blood samples were collected and the polymorphism of Val158Met was carried out using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results No difference was identified in Val158Met polymorphism of genotype (χ²=0.78, P>0.05) and allele (χ²=0.25, P>0.05) among the depression group, the non-depression group and the control group. Conclusion The polymorphism of Val158Met in COMT gene does not contribute to the risk of depression in Parkinson's disease in China.

Key words: Parkinson's disease, depression, catechol-O-methyltransferase, Val158Met, polymorphism

CLC Number:

R742.5

MA Hui-zi, MA Ling-yan, FENG Tao. Relationship between Val158Met Polymorphism in Catechol-O-methyltransferase Gene and Depression in Parkinson's Disease[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(7): 753-756.

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Relationship between Val158Met Polymorphism in Catechol-O-methyltransferase Gene and Depression in Parkinson's Disease

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