CJRTP

《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2004, Vol. 10 ›› Issue (05): 279-280.

• 基础研究 • Previous Articles     Next Articles

Loss of heterozygosity of microsatellite DNA on 6q in bladder tumor

CHENG Fan, CHU Yong-lie, HE Da-lin, et al   

  1. Department of Microbiology, Medical College of Xi'an Jiaotong University, Xi'an 710068,Shaanxi,China
  • Received:2004-03-08 Published:2004-05-25 Online:2004-05-25

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Abstract: ObjectiveTo investigate the loss of heterozygosity (LOH) on 6q in bladder tumor.MethodsD6S404 and D6434 microsatellite markers near 6q21 were tested by PCR-SSLP-stain method on tumor DNA from 31 cases of bladder tumor.ResultsAmong these 31 cases of bladder tumor,LOH was detected in tumor tissues on site for D6S404 (35.5%) and D6S434(22.6%).ConclusionOne or more tumor suppressor gene near 6q21 maybe relevant for the development of bladder tumor.

Key words: bladder tumor, loss of heterozygosity (LOH), long arm of chromosome 6(6q)