汉语发展性阅读障碍儿童全脑静息态功能连接的特征分析

doi:10.3969/j.issn.1006-9771.2025.09.005

《中国康复理论与实践》 ›› 2025, Vol. 31 ›› Issue (9): 1023-1031.doi: 10.3969/j.issn.1006-9771.2025.09.005

• 专题　言语与语言康复 • 上一篇下一篇

汉语发展性阅读障碍儿童全脑静息态功能连接的特征分析

骆丹丹¹^,², 沈敏¹^,³^,⁴(), 王素娟², 邱翁歆², 张宇轩², 吴蕴², 王圣虓⁵

¹ 上海中医药大学康复医学院，上海市 201203
² 复旦大学附属儿科医院，上海市 201102
³ 上海市特殊儿童康复中心，上海市 200127
⁴ 上海交通大学医学院附属上海儿童医学中心，上海市 200127
⁵ 复旦大学附属华山医院静安分院，上海市 200040

收稿日期:2025-01-17 修回日期:2025-09-07 出版日期:2025-09-25 发布日期:2025-10-10
通讯作者: 沈敏(1971-)，女，汉族，江苏南通市人，主任医师，主要研究方向：儿童青少年神经康复，E-mail： minshen223@vip.163.com。
作者简介:骆丹丹(1986-)，女，汉族，上海市人，硕士研究生，主要研究方向：学习障碍。
基金资助:
上海市残联科研项目(2023ZC1006)

Characterisation of whole-brain resting-state functional connectivity in children with Chinese developmental dyslexia

LUO Dandan¹^,², SHEN Min¹^,³^,⁴(), WANG Sujuan², QIU Wengxin², ZHANG Yuxuan², WU Yun², WANG Shengxiao⁵

¹ School of Rehabilitation Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
² Children's Hospital of Fudan University, Shanghai 201102, China
³ Shanghai Rehabilitation Center for Special Children, Shanghai 200127, China
⁴ Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
⁵ Jing'an District Central Hospital/Jing'an Branch, Huashan Hospital, Fudan University, Shanghai 200040, China

Received:2025-01-17 Revised:2025-09-07 Published:2025-09-25 Online:2025-10-10
Contact: SHEN Min, E-mail: minshen223@vip.163.com
Supported by:
Scientific Research Project of Shanghai Disabled Persons' Federation(2023ZC1006)

摘要/Abstract

摘要：

目的采用功能性近红外光谱技术(fNIRS)探究汉语发展性阅读障碍(DD)儿童和典型发育(TD)的健康儿童在静息态下全脑网络的连接特征。

方法 2024年11月至12月，选取复旦大学附属儿科医院6~12岁DD儿童19例(DD组)，同时招募年龄和性别匹配的TD儿童18例(TD组)，选取额叶皮质(FC)、颞叶皮质(TL)、枕叶皮质(OL)和顶叶皮质(PL)脑区为感兴趣区，采用fNIRS采集两组全脑静息态数据，持续5 min。基于氧合血红蛋白在时间序列上的浓度，计算两组静息态下的功能连接强度，比较两组功能连接强度和脑网络的差异。

结果 DD组全脑功能连接强度高于TD组(t = 2.100, P < 0.05)。DD组右侧OL-右侧FC (t = 2.426, P < 0.05)、右侧OL-左侧FC (t = 2.483, P < 0.05)、右侧TL-右侧FC (t = 2.568, P < 0.05)和右侧TL-左侧FC (t = 2.304, P < 0.05)功能连接强度大于TD组。两组全脑功能连接差异的主要区域位于右侧背外侧前额叶皮质、右侧视觉联合皮质、右侧额叶皮质、左侧额眶区、左侧视觉联合皮质、左侧初级视觉皮质和右侧初级皮质运动区。

结论 DD儿童静息态下右侧枕叶、颞叶及二者与前额叶之间的连接强度较强，提示可能存在右脑代偿左脑阅读网络功能不足的现象。

关键词: 发展性阅读障碍, 功能性近红外光谱技术, 静息态, 全脑功能连接

Abstract:

Objective To examine resting-state whole-brain network connectivity in children with Chinese developmental dyslexia (DD) and typically developing (TD) children using functional near-infrared spectroscopy (fNIRS).

Methods From November to December, 2024, 19 DD children aged six to twelve years in Children's Hospital of Fudan University were enrolled, along with 18 TD children matching age and sex. Regions of interest included frontal cortex (FC), temporal lobe (TL), occipital lobe (OL) and parietal lobe (PL). Resting-state data were acquired by fNIRS for five minutes in both groups. Functional connectivity strength was calculated at rest, and between-group differences in connectivity strength and brain networks were compared, based on the time series of oxyhemoglobin concentration.

Results The whole-brain functional connectivity strength was higher in DD group than in TD group (t = 2.100, P< 0.05). Connectivity between the right OL-right FC (t = 2.426, P< 0.05), right OL-left FC (t = 2.483, P < 0.05), right TL-right FC (t = 2.568, P < 0.05) and right TL-left FC (t = 2.304, P < 0.05) were stonger in DD group than in TD group. The major regions exhibiting differences of whole-brain connectivity between two groups were the right dorsolateral prefrontal cortex, right visual association cortex, right frontal cortex, left orbitofrontal cortex, left visual association cortex, left primary visual cortex and right primary motor cortex.

Conclusion Children with DD exhibited significantly stronger connectivity in the right occipital and temporal lobes, as well as between these regions and the prefrontal cortex, suggesting possible right-hemispheric compensation for insufficiency in the left-hemisphere reading network.

Key words: developmental dyslexia, functional near-infrared spectroscopy, resting state, whole-brain functional connectivity

中图分类号:

R749.93

骆丹丹, 沈敏, 王素娟, 邱翁歆, 张宇轩, 吴蕴, 王圣虓. 汉语发展性阅读障碍儿童全脑静息态功能连接的特征分析[J]. 《中国康复理论与实践》, 2025, 31(9): 1023-1031.

LUO Dandan, SHEN Min, WANG Sujuan, QIU Wengxin, ZHANG Yuxuan, WU Yun, WANG Shengxiao. Characterisation of whole-brain resting-state functional connectivity in children with Chinese developmental dyslexia[J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(9): 1023-1031.

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组别	n	性别(男/女)/n	年龄/岁	韦氏IQ
TD组	18	11/7	8.50±1.72	107.88±11.66
DD组	19	12/7	8.31±1.41	100.42±12.43
χ²/t值		0.016	0.356	1.882
P值		0.898	0.724	0.068

ROI	通道排布
左侧FC	CH23、CH22、CH20、CH8、CH10、CH9、CH24
右侧FC	CH19、CH17、CH5、CH7、CH6、CH21
左侧TL	CH33、CH32、CH26、CH27、CH25、CH12、CH11
右侧TL	CH34、CH35、CH2、CH1、CH18、CH4、CH3
左侧PL	CH44、CH31、CH14、CH43、CH30、CH13
右侧PL	CH42、CH16、CH29、CH45、CH15、CH28
左侧OL	CH39、CH40、CH41、CH47、CH48
右侧OL	CH38、CH37、CH36、CH46

ROI	TD组	DD组	t值	P值
右侧OL-右侧FC	0.11	0.28	2.426	0.020
右侧OL-左侧FC	0.08	0.26	2.483	0.017
右侧TL-右侧FC	0.24	0.39	2.568	0.014
右侧TL-左侧FC	0.22	0.33	2.304	0.027

通道	连接通道数	依据 MNI坐标映射脑区分布
CH17	18	右侧背外侧前额叶皮质
CH46	12	右侧视觉联合皮质
CH5	12	右侧额叶皮质
CH8	9	左侧额眶区
CH47	8	左侧视觉联合皮质
CH40	7	左侧初级视觉皮质
CH1	7	右侧初级皮质运动区
CH37	4	右侧初级视觉皮质
CH20	2	左侧额极区
CH30	2	左侧初级躯体感觉皮质
CH36	2	右侧视觉联合皮质

汉语发展性阅读障碍儿童全脑静息态功能连接的特征分析

Characterisation of whole-brain resting-state functional connectivity in children with Chinese developmental dyslexia

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