目的 观察脑梗死患者康复治疗前后血清血管内皮生长因子(VEGF)水平的变化。方法 选取2014年6月~2016年8月本院48例首次脑梗死患者(病例组)，在康复治疗前和康复治疗6周后采用酶联免疫(ELISA)法测定血清VEGF水平，并与33例正常体检者(对照组)的血清VEGF水平进行比较。结果 康复治疗前及康复治疗6周后，病例组VEGF水平均高于对照组(t>2.540, P<0.05)，而且大面积脑梗死(最大梗死直径>4 cm)组的VEGF水平高于小面积脑梗死(最大梗死直径≤4 cm)组(t=4.436, P<0.05)，短病程(≤1个月)脑梗死组的VEGF水平高于长病程(>1个月)组(t=2.316, P<0.05)。结论 康复治疗前后，VEGF均维持较高水平。
卢利萍
,
桑德春
,
白帆
,
陈慧
,
杨帆
,
褚宏宇
,
张晓钰
,
李欣
,
刘建华
. 脑梗死患者康复治疗前后血管内皮生长因子水平的比较[J]. 中国康复理论与实践, 2016
, 22(12)
: 1434
-1433
.
DOI: 10.3969/j.issn.1006-9771.2016.12.015
Objective To investigate the change of serum vascular endothelial growth factor (VEGF) in cerebral infarction before and after rehabilitation.Methods Forty-eight patients with first cerebral infarction were enrolled from June, 2014 to August, 2016 in Beijing Bo'ai Hospital. Level of serum VEGF was measured by enzyme-linked immunosorbent assay (ELISA) before and six weeks after rehabilitation. The level of serum VEGF of 33 normal subjects was compared with the patients'.Results The level of serum VEGF was higher in the patients group than in the control group before and six weeks after rehabilitation (t>2.540, P<0.05). The level of VEGF was higher in the large area infarction group (>4 cm) than in the small area infarction group (≤4 cm) (t=4.436, P<0.05), and was higher in the short course (less than one month) infarction group than in the long course (more than one month) group (t=2.316, P<0.05).Conclusion VEGF can be maintained in high level after rehabilitation.
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