目的 探讨选择性β1受体阻滞剂对高血压患者运动耐力的影响。方法 2015年5月至2016年5月，72例高血压患者按照是否服用选择性β1受体阻滞剂分为两组。A组(n=35)行心肺运动试验前2周服用选择性β1受体阻滞剂，B组(n=37)行心肺运动试验前2周未曾服用任何β受体阻滞剂。两组均行心肺运动试验，比较两组间运动耐力。结果 A组最大收缩压、峰值心率、运动后1 min时心率(HR1)和最大心率血压乘积均低于B组(t>2.012, P<0.05)，而HR1恢复值高于B组(t=2.100, P<0.05)。两组间峰值功率及峰值摄氧量均无显著性差异(t<0.689, P>0.05)。结论 选择性β1受体阻滞剂可降低心肌耗氧量，改善迷走神经张力，并未降低高血压患者的运动耐力。
李寿霖
,
a
,
张焱
,
a
,
刘杰
,
a
,
杨威
,
a
,
刘立君
,
a
,
郑志昌
,
a
,
林伟
,
a
,
王晓荣
,
a
,
王国栋
,
a
,
封丽红
,
a
,
陈思远
,
a
,
杨祖福
,
b
. 选择性β1受体阻滞剂对高血压患者运动耐力的影响[J]. 中国康复理论与实践, 2017
, 23(4)
: 446
-448
.
DOI: 10.3969/j.issn.1006-9771.2017.04.018
Objective To explore the effect of selective beta-1 adrenoreceptor blocker on exercise tolerance in patients with hypertension. Methods From May, 2015 to May, 2016, 72 patients with hypertension were divided into two groups, according to whether taking the selective beta-1 receptor blocker. Group A (n=35) took the selective beta-1 receptor blocker two weeks before cardiopulmonary exercise, while group B (n=37) did not take anything at the same time. The exercise tolerance was compared between two groups. Results The maximal systolic blood pressure, peak heart rate, one-minute heart rate after exercise (HR1) and rate-pressure product were lower in group A than in group B (t>2.012, P<0.05), however, the recovery value of HR1 was higher in group A than in group B (t=2.100, P<0.05). There was no difference in both peak power and peak oxygen uptake between two groups (t<0.689, P>0.05). Conclusion The selective beta-1 adrenoreceptor blocker could reduce myocardial oxygen consumption, and improve vagus nerve activity, but did not reduce exercise tolerance in patients with hypertension.
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