《中国康复理论与实践》

中国康复理论与实践 >

2017 , Vol. 23 >Issue 6: 641 - 644

DOI: https://doi.org/10.3969/j.issn.1006-9771.2017.06.004

专题 脊髓损伤研究

针刺促进脊髓损伤后神经功能恢复的机制及相关信号通路的作用

  • 李华南 ,
  • 张海明 ,
  • 顾兵 ,
  • 原琴琴 ,
  • 闵友江
展开
  • 1.江西中医药大学附属医院创伤骨科,江西南昌市 330006;
    2.江西科技师范大学药学院,江西南昌市 330013。
李华南(1974-),女,汉族,江西南昌市人,博士,主任中医师,副教授,主要研究方向：中医骨伤临床、教学及科研。E-mai: bguemory@msn.com。

收稿日期: 2016-11-21

  修回日期: 2017-01-11

  网络出版日期: 2017-06-27

基金资助

1.国家自然科学基金项目(No.30960448; No.81360562); 2.江西省自然科学基金项目(No.20142BAB205023)

收起

Mechanism of Acupuncture for Recovery of Neurological Function after Spinal Cord Injury and Role of Related Signal Pathway (review)

  • LI Hua-nan ,
  • ZHANG Hai-ming ,
  • GU Bing ,
  • YUAN Qin-qin ,
  • MIN You-jiang
Expand
  • 1. Department of Trauma Orthopedics, the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330006, China;
    2. School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi 330013, China;

Received date: 2016-11-21

  Revised date: 2017-01-11

  Online published: 2017-06-27

Fold

摘要

本文介绍针刺促进脊髓损伤后神经功能恢复的主要生物学机制,包括抑制炎症反应和氧化应激,减轻神经病理性疼痛,增加神经营养活性物质,调节细胞生存/凋亡基因和神经再生信号通路。

关键词： 脊髓损伤; 针刺; 神经功能; 氧化应激; 神经病理性疼痛; 凋亡; 信号通路; 综述

本文引用格式

李华南 , 张海明 , 顾兵 , 原琴琴 , 闵友江 . 针刺促进脊髓损伤后神经功能恢复的机制及相关信号通路的作用[J]. 中国康复理论与实践, 2017 , 23(6) : 641 -644 . DOI: 10.3969/j.issn.1006-9771.2017.06.004

Abstract

This article introduced the main biological mechanisms of acupuncture promoting nerve function recovery after spinal cord injury, which include inhibition of inflammation and oxidative stress, alleviation of neuropathic pain, increase of neurotrophic active substance, regulation of cell survival/apoptosis gene and neural regeneration pathway.

Key words： spinal cord injury; acupuncture; nerve function; oxidative stress; neuropathic pain; apoptosis; signal pathway; review

参考文献

[1] Heo I, Shin BC, Kim YD, et al. Acupuncture for spinal cord injury and its complications: a systematic review and meta-analysis of randomized controlled trials [J]. Evid Based Complement Alternat Med, 2013, 2013: 364216.
[2] Shin BC, Lee MS, Kong JC, et al. Acupuncture for spinal cord injury survivors in Chinese literature: a systematic review [J]. Complement Ther Med, 2009, 17(5-6): 316-327.
[3] 王冰. 黄帝内经[M]. 北京:中国科学技术出版社, 1997: 610
[4] 赵献可. 医贯[M]. 北京:中国中医药出版社, 2009: 31.
[5] 郭霭春,郭洪图. 八十一难经集解[M]. 天津:天津科学技术出版社, 1984: 135.
[6] 钱宝延,蔡西国,马玉娟,等. 电针俞募穴治疗脊髓损伤后神经源性膀胱的临床观察[J]. 中国康复医学杂志, 2016, 31(1): 50-53.
[7] Norrbrink C, Lundeberg T. Acupuncture and massage therapy for neuropathic pain following spinal cord injury: an exploratory study [J]. Acupunct Med, 2011, 29(2): 108-115.
[8] 余鸿斌,于柏清,杜振欢,等. 涌泉穴烧山火针法治疗脊髓损伤临床观察[J]. 上海针灸杂志, 2015, 34(8): 773-774.
[9] 徐秀梅,徐彦龙. 康复训练结合针灸治疗脊髓损伤神经源性膀胱患者临床疗效观察[J]. 中国针灸, 2015, 35(7): 670-673.
[10] Gu XD, Wang J, Yu P, et al. Effects of electroacupuncture combined with clean intermittent catheterization on urinary retention after spinal cord injury: a single blind randomized controlled clinical trial [J]. Int J Clin Exp Med, 2015, 8(10): 19757-19763.
[11] Ma R, Liu X, Clark J, et al. The impact of acupuncture on neurological recovery in spinal cord injury: a systematic review and meta-analysis [J]. J Neurotrauma, 2015, 32(24): 1943-1957.
[12] 王赛,邹恩苗,林海燕,等. 夹脊、督脉电针对大鼠脊髓损伤前炎性细胞因子表达的影响[J]. 中国康复医学杂志, 2013, 28(5): 389-392.
[13] 邹恩苗,王赛,李江筎,等. 针刺水沟、风府穴对急性大鼠脊髓损伤后前炎性因子表达的影响[J]. 中国中医急症, 2013, 22(6): 883-886.
[14] Jiang SH, Tu WZ, Zou EM, et al. Neuroprotective effects of different modalities of acupuncture on traumatic spinal cord injury in rats [J]. Evid Based Complement Alternat Med, 2014: 431580.
[15] Choi DC, Lee JY, Moon YJ, et al. Acupuncture-mediated inhibition of inflammation facilitates significant functional recovery after spinal cord injury [J]. Neurobiol Dis, 2010, 39(3): 272-282.
[16] 宋琳,李晓宁,王莹威,等. 电针对急性脊髓损伤大鼠氧化应激反应的影响[J]. 针灸临床杂志, 2011, 27(1): 55-57.
[17] Juarez Becerril O, Salgado Ceballos H, Anguiano Solis C, et al. Electro-acupuncture at GV.4 improves functional recovery in paralyzed rats after a traumatic spinal cord injury [J]. Acupunct Electrother Res, 2015, 40(4): 355-369.
[18] 薛己. 正体类要[M]. 丁继华,曹炳章. 北京: 人民卫生出版社, 2006: 53.
[19] Gwak YS, Kim HY, Lee BH, et al. Combined approaches for the relief of spinal cord injury-induced neuropathic pain [J]. Complement Ther Med, 2016, 25: 27-33.
[20] 王彧,李瑛,胡幼平,等. “养心通督”针法治疗脊髓损伤后中枢性疼痛58例[J]. 中国针灸, 2014, 34(1): 88.
[21] 李小宏,谢德娟,余和平, 等. 综合疗法治疗脊髓损伤后中枢性疼痛32例临床观察[J]. 中国康复理论与实践, 2009, 15(2): 112-113.
[22] 张文龙,施彬彬,周然宓. 论提高肌肉运动的协同性是针灸镇痛的重要机制之一[J]. 中国针灸, 2016, 36(2): 200-202.
[23] Estores I, Chen K, Jackson B, et al. Auricular acupuncture for spinal cord injury related neuropathic pain: a pilot controlled clinical trial [J]. J Spinal Cord Med, 2016, 15: 1-7.
[24] Zhao ZQ. Neural mechanism underlying acupuncture analgesia [J]. Prog Neurobiol, 2008, 85(4): 355-375.
[25] Chen XM, Xu J, Song JG, et al. Electroacupuncture inhibits excessive interferon-γ evoked up-regulation of P2X4 receptor in spinal microglia in a CCI rat model for neuropathic pain [J]. Br J Anaesth, 2015, 114(1): 150-157.
[26] Yu J, Zhao C, Luo X. The effects of electroacupuncture on the extracellular signal-regulated kinase 1/2/P2X3 signal pathway in the spinal cord of rats with chronic constriction injury [J]. Anesth Analg, 2013, 116(1): 239-246.
[27] Lee JY, Choi DC, Oh TH, et al. Analgesic effect of acupuncture is mediated via inhibition of JNK activation in astrocytes after spinal cord injury [J]. PLoS One, 2013, 8(9): e73948.
[28] Fang JQ, Fang JF, Liang Y, et al. Electroacupuncture mediates extracellular signal-regulated kinase 1/2 pathways in the spinal cord of rats with inflammatory pain [J]. BMC Complement Altern Med, 2014, 14: 285.
[29] Kim JH, Kim SH, Cho SR, et al. The modulation of neurotrophin and epigenetic regulators: implication for astrocyte proliferation and neuronal cell apoptosis after spinal cord injury [J]. Ann Rehabil Med, 2016, 40(4): 559-567.
[30] Mo YP, Yao HJ, Lv W, et al. Effects of electroacupuncture at governor vessel acupoints on neurotrophin-3 in rats with experimental spinal cord injury [J]. Neural Plast, 2016, 2016: 2371875.
[31] 王俊华,陈邦国,尹晶,等. 电针不同穴位对脊髓损伤后尿潴留大鼠脊髓中脑源性神经营养因子及其酪氨酸受体激酶B表达的影响[J]. 针刺研究, 2009, 34(6): 387-392.
[32] Yang JH, Lv JG, Wang H, et al. Electroacupuncture promotes the recovery of motor neuron function in the anterior horn of the injured spinal cord [J]. Neural Regen Res, 2015, 10(12): 2033-2039.
[33] 刘鹏民,李灵玲,王良,等. 督脉电针结合游泳训练对大鼠全横断脊髓损伤后GAP-43和Nogo-A表达的影响[J]. 中国康复医学杂志, 2016, 31(4): 399-404.
[34] 李兵奎,曾彬,常巍,等. 督脉电针对脊髓损伤大鼠生长相关蛋白43表达的影响[J]. 中国康复理论与实践, 2014, 20(1): 27-29.
[35] 李惠兰,刘兰群,卢虎英,等. 减重步行训练和督脉电针对脊髓损伤大鼠神经营养因子及生长相关蛋白-43表达的影响[J]. 中国康复理论与实践, 2012, 18(10): 930-933.
[36] 吕威,莫雨平,李冰,等. 督脉电针对不同时间段脊髓损伤大鼠运动功能及p75神经营养素受体表达的影响[J]. 中国康复理论与实践, 2016, 22(8): 876-883.
[37] 吕威,姚海江,莫雨平,等. 脊髓损伤后神经再生相关信号通路研究进展[J]. 中国康复理论与实践, 2016, 22(3): 293-298.
[38] Zhao W, Zhao Q, Liu J, et al. Electro-acupuncture reduces neuronal apoptosis linked to Bax and Bcl-2 expression in the spinal cords of cats subjected to partial dorsal root ganglionectomy [J]. Neurochem Res, 2008, 33(11): 2214-2221.
[39] 时素华,李志刚,宋萌,等. 电针对大鼠脊髓损伤后细胞凋亡受体及肿瘤坏死因子1表达的影响[J]. 吉林中医药, 2011, 31(1): 73-77.
[40] 柯晓华,葛杜鹃,王文春,等. 运动点电针对急性脊髓损伤大鼠半胱氨酸天冬氨酸蛋白酶3和降钙素基因相关肽表达的影响[J]. 中国康复医学杂志, 2014, 29(10): 913-917.
[41] 陈荣良,全仁夫,许世超,等. 芒针透刺抗急性脊髓损伤细胞凋亡的信号转导机制[J]. 针刺研究, 2014, 39(4): 259-277.
[42] Quan RF, Chen RL, Du MX, et al. Anti-apoptotic signal transduction mechanism of electroacupuncture in acute spinal cord injury [J]. Acupunct Med, 2014, 32(6): 463-471.
[43] 唐祎周,孙忠人,张翀. 夹脊电针对脊髓损伤大鼠内质网应激相关因子IRE1影响的实验研究[J]. 针灸临床杂志, 2013, 29(8): 55-58.
[44] Choi DC, Lee JY, Lim EJ, et al. Inhibition of ROS-induced p38MAPK and ERK activation in microglia by acupuncture relieves neuropathic pain after spinal cord injury in rats [J]. Exp Neurol, 2012, 236(2): 268-282.
[45] Fang JQ, Du JY, Liang Y, et al. Intervention of electroacupuncture on spinal p38MAPK/ATF-2/VR-1 pathway in treating inflammatory pain induced by CFA in rats [J]. Mol Pain, 2013, 9: 13.
[46] Shi Y, Quan R, Li C, et al. The study of traditional Chinese medical elongated-needle therapy promoting neurological recovery mechanism after spinal cord injury in rats [J]. J Ethnopharmacol, 2016, 187: 28-41.
Options
文章导航

/

〈 〉