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肌萎缩侧索硬化发病机制的研究进展

  • 郭永强 ,
  • 李森 ,
  • 张海鸿 ,
  • 伍亚民
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  • 1.第三军医大学大坪医院野战外科研究所三室,创伤、烧伤与复合伤国家重点实验室,重庆市400042;
    2.兰州大学第二医院骨科,甘肃兰州市 730030。
郭永强(1990-),男,汉族,甘肃岷县人,硕士研究生,主要研究方向:脊柱脊髓损伤。

收稿日期: 2017-01-13

  修回日期: 2017-02-13

  网络出版日期: 2017-06-27

Advance in Pathogenesis of Amyotrophic Lateral Sclerosis (review)

  • GUO Yong-qiang ,
  • LI Sen ,
  • ZHANG Hai-hong ,
  • WU Ya-min
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  • 1. State Key Laboratory of Trauma, Burns and Combined Injury, the Third Department of Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China;
    2. Department of Orthopedics, Second Clinical Medical College of Lanzhou University, Lanzhou, Gansu 730030, China

Received date: 2017-01-13

  Revised date: 2017-02-13

  Online published: 2017-06-27

摘要

肌萎缩侧索硬化(ALS)是最常见的一种运动神经元疾病,分为家族性和散发性。一般认为,ALS的发病机制主要包括基因突变、氧化应激、兴奋毒性、线粒体异常和免疫炎症反应等。这些发病机制之间相互联系,相互影响,最终引起了以运动神经系统为主的多系统病变。

本文引用格式

郭永强 , 李森 , 张海鸿 , 伍亚民 . 肌萎缩侧索硬化发病机制的研究进展[J]. 中国康复理论与实践, 2017 , 23(6) : 685 -689 . DOI: 10.3969/j.issn.1006-9771.2017.06.014

Abstract

Amyotrophic lateral sclerosis (ALS), including the familial and the sporadic, accounts for the most proportion of motor neuron disease. The pathogenesis of ALS covers gene mutation, oxidative stress, excitotoxicity, mitochondrial dysfunction, immune and inflammatory, and so on. With interplay and interrelation, these mechanisms, finally, caused multisystem lesion especially motor neural system.

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