基础研究

MicroRNAs与脊髓损伤的研究进展

  • 张政佩 ,
  • 余铃 ,
  • 孙祥然 ,
  • 郭卫春
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  • 武汉大学人民医院骨I科,湖北武汉市 430060
张政佩(1990-),男,汉族,湖北黄石市人,硕士研究生,主要研究方向:microRNA、脊髓损伤、骨折。

收稿日期: 2017-03-13

  修回日期: 2017-04-24

  网络出版日期: 2017-11-03

基金资助

1.国家自然科学基金项目(No.81502575); 2.中央高校基本科研业务费专项资金项目(No.2042015kf0069)

Advance of microRNAs for Spine Cord Injury (review)

  • ZHANG Zheng-pei ,
  • YU Ling ,
  • SUN Xiang-ran ,
  • GUO Wei-chun
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  • Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China

Received date: 2017-03-13

  Revised date: 2017-04-24

  Online published: 2017-11-03

摘要

] 脊髓损伤是一种严重的中枢神经系统性创伤,导致损伤节段以下运动和感觉功能障碍。治疗脊髓损伤的方法主要围绕恢复继发性损伤和促进再生来开展。microRNAs (miRNAs)在脊髓损伤所导致的继发性损伤和促进再生中扮演着重要角色。本文进一步的阐述不同亚型miRNA在脊髓损伤中所起的作用,同时评价这些miRNA作为脊髓损伤治疗靶点的研究前景。

本文引用格式

张政佩 , 余铃 , 孙祥然 , 郭卫春 . MicroRNAs与脊髓损伤的研究进展[J]. 中国康复理论与实践, 2017 , 23(10) : 1152 -1156 . DOI: 10.3969/j.issn.1006-9771.2017.10.006

Abstract

Spine cord injury is a kind of severe central nervous system trauma causing motion and sensation dysfunction. Treatment focuses on controlling secondary injury cascade and improving regeneration which are heavily regulated by microRNAs (miRNAs). This review discussed the effect of miRNAs with different subtypes on spine cord injury, and investigated their potential roles as therapeutic agents in the personalized treatment of patients with spine cord injury.

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