《中国康复理论与实践》

中国康复理论与实践 >

2018 , Vol. 24 >Issue 3: 266 - 268

DOI: https://doi.org/10.3969/j.issn.1006-9771.2017.00.001

基础研究

脊髓损伤后恒河猴双下肢体重支撑的改变

  • 赵文 ,
  • 魏瑞晗 ,
  • 饶家声 ,
  • 赵璨 ,
  • 田鹏宇 ,
  • 周侠 ,
  • 季润 ,
  • 李立峰 ,
  • 杨朝阳 ,
  • 李晓光
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  • 1.首都医科大学神经生物学系,北京市 100069;
    2.北京航空航天大学生物材料和神经再生北京市实验室,生物医学工程学院,北京市 100191;
    3.国家康复辅具研究中心人体生物力学实验室,北京市 100176
赵文(1990-),女,汉族,河北邢台市人,硕士,技师,主要研究方向：应用组织工程学方法修复脊髓损伤的行为学评价。通讯作者：李晓光(1959-),男,吉林长春市人,博士,教授,主要研究方向：应用组织工程学的方法修复神经系统损伤的研究。

收稿日期: 2017-11-13

  修回日期: 2017-12-07

  网络出版日期: 2018-03-27

基金资助

1.国家重点研发计划(No. 2017YFC1104002; No. 2017YFC1104001); 2.国家自然科学基金面上项目(No. 31670988; No. 31771053); 3.国家自然科学基金应急管理项目(No. 31650001); 4.国家自然科学基金国际(地区)合作与交流项目(No. 31320103903); 5.高等学校全国优秀博士学位论文作者专项资金资助项目(No. 201356); 6.国家自然科学基金重点项目(No. 31730030); 7.北京市科技计划(No. Z171100002217066)

收起

Impairment of Weight Support of Lower Limbs after Spinal Cord Hemi-section in Rhesus Monkeys

  • ZHAO Wen ,
  • WEI Rui-han ,
  • RAO Jia-sheng ,
  • ZHAO Can ,
  • TIAN Peng-yu ,
  • ZHOU Xia ,
  • JI Run ,
  • LI Li-feng ,
  • YANG Zhao-yang ,
  • LI Xiao-guang
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  • 1. Department of Neurobiology, Capital Medical University, Beijing 100069, China;
    2. Beijing Key Laboratory for Biomaterials and Neural Regeneration, Department of Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China;
    3. Human Biomechanics Laboratory, National Research Center for Rehabilitation Technical Aids, Beijing 100176, China

Received date: 2017-11-13

  Revised date: 2017-12-07

  Online published: 2018-03-27

Supported by

Supported by National Key Research and Development Program (No. 2017YFC1104002; No. 2017YFC1104001); National Natural Science Foundation of China, Key Program (No. 31730030), General Program (No. 31670988; No. 31771053), Emergency Management Program (No. 31650001), Projects of International Cooperation and Exchanges (No. 31320103903); Special Funds for the Authors of Excellent Doctoral Dissertations of Universities and Colleges (No. 201356); and Beijing Science and Technology Program (No. Z171100002217066)

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摘要

目的 观察脊髓损伤对肢体承重能力的影响,揭示脊髓损伤后下肢承重能力随时间的变化规律。方法 6只成年雌性恒河猴行T7-9右半侧1 cm切除术。采用Foot-Scan系统测量恒河猴脊髓损伤前,损伤后6周、12周时双下肢足底压力百分比。结果 损伤前,双下肢足底压力百分比无显著性差异(Z=-1.330, P>0.05);损伤后6周和12周,左下肢足底压力百分比显著高于右下肢(Z>4.783, P<0.001)。损伤前后,右下肢足底压力百分比呈现逐步显著下降趋势(Z=3.191, P<0.001)。结论 脊髓损伤后,损伤侧下肢承重能力严重缺失,不经干预则呈持续下降趋势。

关键词： 脊髓损伤; 下肢; 体重; 支撑; 恒河猴

本文引用格式

赵文 , 魏瑞晗 , 饶家声 , 赵璨 , 田鹏宇 , 周侠 , 季润 , 李立峰 , 杨朝阳 , 李晓光 . 脊髓损伤后恒河猴双下肢体重支撑的改变[J]. 中国康复理论与实践, 2018 , 24(3) : 266 -268 . DOI: 10.3969/j.issn.1006-9771.2017.00.001

Abstract

Objective To observe the influence of spinal cord injury on lower limbs weight support capacity, and the changes with time. Methods Six adult female rhesus monkeys with thoracic (T7-9) right spinal cord hemi-section were measured the plantar pressure ratio of both lower limbs with Foot-Scan system before, and six and twelve weeks after operation. Results There was no statistical difference between both sides of limbs before operation (Z=-1.330, P>0.05), while the plantar pressure ratio was more on the left limbs six and twelve weeks after operation (Z>4.783, P<0.001). The plantar pressure ratio of right lower limb became less and less during observation (Z=3.191, P<0.001).Conclusion The weight support capacity of affected limbs is injured after spinal cord hemi-section in monkeys, and would become worse without intervention.

Key words： spinal cord injury; lower limbs; body weight; support; rhesus monkeys

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