《中国康复理论与实践》

中国康复理论与实践 >

2019 , Vol. 25 >Issue 5: 553 - 556

DOI: https://doi.org/10.3969/j.issn.1006-9771.2019.05.010

临床研究

DRD3基因Ser9Gly多态性与中国帕金森病抑郁的关系

  • 马凌燕 ,
  • 马惠姿 ,
  • 冯涛
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  • 1.首都医科大学附属北京天坛医院神经病学中心运动障碍性疾病科，北京市 100070
    2.国家神经系统疾病临床医学研究中心，北京市 100070
    3.北京脑重大疾病研究院帕金森病研究所，北京市 100070
马凌燕(1985-)，女，汉族，山东青岛市人，博士，主治医师，主要研究方向：帕金森病及运动障碍病遗传、分型、脑网络等。

收稿日期: 2018-10-17

  修回日期: 2018-12-10

  网络出版日期: 2019-05-29

基金资助

1.北京市自然科学基金项目(No. 7164254)；2.国家自然科学基金面上项目(No. 81571226; No. 81771367)；3.首都特色临床应用研究项目(No. Z171100001017041)；4.北京市科委基金项目(No. Z151100003915150)；5."十三 五”国家重点研发计划项目(No. 2016YFC1306501)

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Association between Ser9Gly Polymorphism of DRD3 Gene and Depression in Parkinson's Disease

  • MA Ling-yan ,
  • MA Hui-zi ,
  • FENG Tao
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  • 1.Center of Movement Disorder, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
    2.China National Clinical Research Center for Neurological Disease, Beijing 100070, China
    3.Parkinson's Disease Center, Beijing Institute for Brain Disorder, Beijing 100070, China

Received date: 2018-10-17

  Revised date: 2018-12-10

  Online published: 2019-05-29

Supported by

Beijing Natural Science Foundation (No. 7164254), National Natural Science Foundation of China (General) (No. 81571226; No. 81771367), Capital Clinical Application Research Program (No. Z171100001017041), Beijing Science and Technology Commission Fund (No. Z151100003915150) and National Key Research and Development Program (No. 2016YFC1306501)

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摘要

目的 探讨多巴胺D3受体(DRD3)基因Ser9Gly多态性与中国帕金森病抑郁的相关性。方法 2016年6月至2018年6月，散发帕金森病患者312例根据汉密尔顿抑郁量表评分分为抑郁组(n = 132)和非抑郁组(n = 180)。同时招募性别和年龄匹配的健康体检者252例为对照组。留取外周血提取基因组DNA，采用限制性片段长度多态性-聚合酶链反应和限制性酶切方法检测DRD3基因Ser9Gly多态位点。结果 三组DRD3基因Ser9Gly位点基因型和等位基因型分布无显著性差异(χ2 = 3.095, χ2 = 2.627, P > 0.05)。结论 DRD3基因Ser9Gly多态性并非中国帕金森病抑郁人群的遗传易感因素。

关键词： 帕金森病; 抑郁; DRD3基因; Ser9Gly; 多态性

本文引用格式

马凌燕 , 马惠姿 , 冯涛 . DRD3基因Ser9Gly多态性与中国帕金森病抑郁的关系[J]. 中国康复理论与实践, 2019 , 25(5) : 553 -556 . DOI: 10.3969/j.issn.1006-9771.2019.05.010

Abstract

Objectives To explore the relationship between the dopamine D3 receptor (DRD3) polymorphism on Ser9Gly and depression in Parkinson's disease (PD).Methods From June, 2016 to June, 2018, 312 Chinese patients with PD were divided into depression group (n = 132) and non-depression group (n = 180) according to scores of Hamilton Depression Scale. A total of 252 age- and gender-matched healthy subjects were recruited as control group. Their blood samples were collected. Genotyping of Ser9Gly polymorphism was carried out using polymerase chain reaction-restriction fragment length polymorphism. Results No statistical difference was identified in Ser9Gly polymorphism among three groups in both gene types and allel (χ2 = 3.095, χ2 = 2.627, P > 0.05). Conclusion Ser9Gly polymorphism in DRD3 gene may not be a susceptible factor for depression in PD in China.

Key words： Parkinson's disease; depression; DRD3; Ser9Gly; polymorphism

参考文献

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