运动对骨代谢信号通路影响的研究进展

doi:10.3969/j.issn.1006-9771.2016.12.013

Abstract

Abstract: The process of exercise regulating bone metabolism is complicated, which involves a number of signaling pathways. A large number of studies in vitro have indicated that mechanical stress regulates bone metabolism by Wnt, bone morphogenetic protein (BMP), and osteoprotegerin (OPG)/ receptor activator of NF-κB ligand (RANKL)/ receptor activator of NF-κB (RANK) signaling pathways. Both the intensity and frequency of mechanical stress have varing impact on bone tissue and cells. Plenty of studies in vivo also have shown that exercise regulates bone metabolism by key factors in bone metabolism signaling pathways. This paper reviewed the effects of exercise on bone metabolism pathways and their mechanisms.

Key words: exercise, mechanical stress, bone metabolism pathway, review

CLC Number:

R336

TONG Xiao-yang, ZHANG Ling-li, GUO Jian-min, YUAN Yu, ZOU Jun. Advance in Exercise for Bone Metabolism Pathways (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2016, 22(12): 1425-1424.

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Advance in Exercise for Bone Metabolism Pathways (review)

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