《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2019, Vol. 25 ›› Issue (10): 1146-1149.doi: 10.3969/j.issn.1006-9771.2019.10.006

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Advance in Minocycline for Spinal Cord Injury (review)

YAN Rong-bao, QI Quan, LIU Yang, ZHAO Peng, LI Cheng-yong, YIN Xun-yi   

  1. Department of Orthopedics, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China
  • Published:2019-10-25 Online:2019-10-30
  • Contact: QI Quan, E-mail: qiquan_harbin@163.com E-mail:qiquan_harbin@163.com
  • Supported by:
    Supported by Foundation:Harbin Special Funds Project for Research of Scientific and Technological Innovative Talents (No. 2017RAQXJ185) and Heilongjiang Natural Science Foundation (No. D201262)

Abstract: The treatment of spinal cord injury has been the research priorities in basic and clinical medicine. This article described the mechanism of minocycline in treating spinal cord injury, including antioxidant activity, reduction of apoptosis, anti-inflammatory activity and selective regulation of microglia activation, and recent advances in clinical trials of minocycline. Minocycline targets multiple secondary injury mechanisms to promote the recovery of spinal cord injury, and further basic and clinical research will maximize the efficacy of minocycline.

Key words: minocycline, spinal cord injury, mechanism, clinical research, review

CLC Number: