《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2019, Vol. 25 ›› Issue (12): 1434-1438.doi: 10.3969/j.issn.1006-9771.2019.12.011

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Potential Impact of Gut Microbiota on Spinal Cord Injury (review)

ZHAO Xiao-hua1,2, ZHOU Rui-han1,2, GUO Wei3, PANG Ri-zhao2, WANG Wen-chun2, ZHANG An-ren2   

  1. 1.School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China
    2.Department of Rehabilitation Medicine, the General Hospital of Western Theater Command, Chengdu, Sichuan 610083, China
    3.Pre-treatment Center of Leshan Traditional Chinese Medicine Hospital, Leshan, Sichuan 614000, China
  • Received:2019-05-13 Revised:2019-06-03 Published:2019-12-25 Online:2019-12-26
  • Contact: ZHANG An-ren, E-mail: 1518526780@qq.com E-mail:1518526780@qq.com
  • Supported by:
    Supported by National Natural Science Foundation of China (No. 81674044)

Abstract: With the deepening of microbial research in central nervous system diseases, the role of gut microbiota in spinal cord injury has also received extensive attention. At present, it is mainly focused on exploring the changes of gut microbiota after spinal cord injury and the potential effects of aryl hydrocarbon receptor agonists, short-chain fatty acids and lipopolysaccharides produced by bacterial metabolism on secondary inflammation after injury, and it is recognized that gut microbiota or supplemental flora metabolites may be a potential pathway for the treatment of spinal cord injury.

Key words: spinal cord injury, gut microbiota, inflammation, metabolites, aryl hydrocarbon receptor, short-chain fatty acids, lipopolysaccharides, review

CLC Number: