CJRTP

Chinese Journal of Rehabilitation Theory and Practice >

2016 , Vol. 22 >Issue 9: 1011 - 1014

DOI: https://doi.org/10.3969/j.issn.1006-9771.2016.09.005

Effect of Electroacupuncture on Expression of Phosphodiesterase 4 and Subtypes in Hippocampus in Rats with Chronic Stress Depression

  • JING Quan-kai1 ,
  • SAIYIN Chao-ke-tu2 ,
  • YAO Hai-jiang3 ,
  • 4 ,
  • Lü Wei1 ,
  • AOCUN You-dou1 ,
  • YANG Li-juan1 ,
  • LIU Jun-tong1 ,
  • LI Zhi-gang1
Expand
  • 1. Department of Acupuncture and Massage, Beijing University of Chinese Medicine, Beijing 100029, China; 2. Inner Mongolia International Mongolian Hospital Traditional Therapy Technique, Hohhot, Inner Mongolia 010065, China; 3. Treatment Center of Traditional Chinese Medicine, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China; 4. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China

Online published: 2016-12-05

Fold

Abstract

Objective To explore the biological mechanisms of electroacupuncture (EA) for depression. Methods Forty male adult Sprague-Dawley rats were randomly divided into control group (n=8), model group (n=8), EA group (n=8) and fluoxetine group (n=8). Depressive models were established with lonely raising and chronic unpredictable mild stress. They were tested with Open-field Test, and the expression of phosphodiesterase 4 (PDE4)A and PDE4D in hippocampus was detected with RT-PCR. Results The cross and rear scores were significantly lower in the model group than in the control group (P<0.001), while it increased in the EA group and the fluoxetine group (P<0.001). Compared with the model group, the expression of PDE4A and PDE4D decreased in the EA group (P<0.001). Conclusion Electroacupuncture may relieve depression through inhibiting the expression of PDE4A and PDE4D.

Key words： depression; electroacupuncture; chronic stress; phosphodiesterase 4; rats

Cite this article

JING Quan-kai1 , SAIYIN Chao-ke-tu2 , YAO Hai-jiang3 , 4 , Lü Wei1 , AOCUN You-dou1 , YANG Li-juan1 , LIU Jun-tong1 , LI Zhi-gang1 . Effect of Electroacupuncture on Expression of Phosphodiesterase 4 and Subtypes in Hippocampus in Rats with Chronic Stress Depression[J]. Chinese Journal of Rehabilitation Theory and Practice, 2016 , 22(9) : 1011 -1014 . DOI: 10.3969/j.issn.1006-9771.2016.09.005

Options
Outlines

/

〈 〉