Mechanism of Neural Stem and Progenitor Cells Mediated by Hypoxia Inducible Factor-1α in Ischemic Stroke Model (review)

  • ZHANG Dong-yuan ,
  • LI Ming ,
  • WANG Zheng-ze ,
  • ZHANG Wen-ran ,
  • XU Xiao-dan ,
  • ZHANG Li- ying ,
  • TIAN Shen
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  • Department of Neurology, the Forth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, China

Received date: 2016-11-15

  Online published: 2017-03-31

Abstract

Hypoxia inducible factor-1α is a kind of hypoxia response factor. Acute cerebral ischemia and anoxia can induce up-regulation of hypoxia inducible factor-1α, and the downstream genes, which plays a role in both the energy metabolism and collateral circulation after cerebral ischemia. Neural stem and progenitor cells regeneration also benefit the functional outcome after ischemic stroke. Hypoxia inducible factor-1α may induce proliferation and differentiation of neural stem and progenitor cells through Notch, Wnt/β-catenin pathways, etc., in the ischemic stroke model.

Cite this article

ZHANG Dong-yuan , LI Ming , WANG Zheng-ze , ZHANG Wen-ran , XU Xiao-dan , ZHANG Li- ying , TIAN Shen . Mechanism of Neural Stem and Progenitor Cells Mediated by Hypoxia Inducible Factor-1α in Ischemic Stroke Model (review)[J]. Chinese Journal of Rehabilitation Theory and Practice, 2017 , 23(3) : 319 -322 . DOI: 10.3969/j.issn.1006-9771.2017.03.015

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