[1] Clevers H, Nusse R. Wnt/β-catenin signaling and disease [J]. Cell, 2012, 149(6): 1192-1205.
[2] Martin BL, Kimelman D. Canonical Wnt signaling dynamically controls multiple stem cell fate decisions during vertebrate body formation [J]. Dev Cell, 2012, 22(1): 223-232.
[3] Huang MY, Yen LC, Liu HC, et al. Significant overexpression of DVL1 in Taiwanese colorectal cancer patients with liver metastasis [J]. Int J Mol Sci, 2013, 14(10): 20492-20507.
[4] Bienz M. Signalosome assembly by domains undergoing dynamic head-to-tail polymerization [J]. Trends Biochem Sci, 2014, 39(10): 487-495.
[5] Hino S, Michiue T, Asashima M, et al. Casein kinase1 epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin [J]. J Biol Chem, 2003, 278(16): 14066-14073.
[6] Gammons MV, Renko M, Johnson CM, et al. Wnt signalosome assembly by DEP domain swapping of Dishevelled [J]. Mol Cell, 2016, 64(1): 92-104.
[7] Xu W, He X. DEEP insights through the DEP Domain [J]. Structure, 2010, 18(10): 1223-1225.
[8] Simons M, Gault WJ, Gotthardt D, et al. Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization [J]. Nat Cell Biol, 2009, 11(3): 286-294.
[9] Capelluto DG, Zhao X, Lucas A, et al. Biophysical and molecular-dynamics studies of phosphatidic acid binding by the Dvl-2 DEP domain [J]. Biophys J, 2014, 106(5): 1101-1111.
[10] Jiang X, Charlat O, Zamponi R, et al. Dishevelled promotes Wnt receptor degradation through recruitment of ZNRF3/RNF43 E3 ubiquitin ligases [J]. Mol Cell, 2015, 58(3): 522-533.
[11] Gammons MV, Rutherford TJ, Steinhart Z, et al. Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay [J]. J Cell Sci, 2016, 129(20): 3892-3902.
[12] Tauriello DV, Jordens I, Kirchner K, et al. Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled [J]. Proc Natl Acad Sci U S A, 2012, 109(14): E812-E820.
[13] Consonni SV, Maurice MM, Bos JL. DEP domains: structurally similar but functionally different [J]. Nat Rev Mol Cell Biol, 2014, 15(5): 357-362.
[14] Dillman AR, Minor PJ, Sternberg PW. Origin and evolution of disheveled [J]. G3 (Bethesda), 2013, 3(2): 251-262.
[15] Gan XQ, Wang JY, Xi Y, et al. Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction [J]. J Cell Biol, 2008, 180(6): 1087-1100.
[16] Tada M, Kai M. Noncanonical Wnt/PCP signaling during vertebrate gastrulation [J]. Zebrafish, 2009, 6(1): 29-40.
[17] Strutt DI. The asymmetric subcellular localisation of components of the planar polarity pathway [J]. Semin Cell Dev Biol, 2002, 13(3): 225-231.
[18] Bastock R, Strutt H, Strutt D. Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning [J]. Development, 2003, 130(13): 3007-3014.
[19] Schulte G, Bryja V. The Frizzled family of unconventional G-protein-coupled receptors [J]. Trends Pharmacol Sci, 2007, 28(10): 518-525.
[20] Gao C, Chen YG. Dishevelled: The hub of Wnt signaling [J]. Cell Signal, 2010, 22(5): 717-727.
[21] Bernatík O, Sedová K, Schille C, et al. Functional analysis of dishevelled-3 phosphorylation identifies distinct mechanisms driven by casein kinase 1ϵ and frizzled5 [J]. J Biol Chem, 2014, 289(34): 23520-23533.
[22] Wei W, Li M, Wang J, et al. The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein [J]. Mol Cell Biol, 2012, 32(19): 3903-3912.
[23] Jung H, Kim HJ, Lee SK, et al. Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled [J]. Exp Mol Med, 2009, 41(10): 695-706.
[24] Lee HJ, Shi DL, Zheng JJ. Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways [J]. Elife, 2015, 4: e08142.
[25] Davies J, Zachariades E, Rogers-Broadway KR, et al. Elucidating the role of DEP TOR in Alzheimer's disease [J]. Int J Mol Med, 2014, 34(5): 1195-1200.
[26] Gravel M, Iliescu A, Horth C, et al. Molecular and cellular mechanisms underlying neural tube defects in the loop-tail mutant mouse [J]. Biochemistry, 2010, 49(16): 3445-3455.
[27] 刘阳,张庆华,张莉,等. Wnt/PCP-JNK信号通路在牛磺酸预防小鼠神经管畸形中的介导作[J]. 中华神经外科杂志, 2014, 30(11): 1175-1178.
[28] Wu G, Huang X, Hua Y, et al. Roles of planar cell polarity pathways in the development of neural tube defects [J]. J Biomed Sci, 2011, 18: 66.
[29] Chen S, Zhang Q, Bai B, et al. MARK2/Par1b insufficiency attenuates DVL gene transcription via histone deacetylation in lumbosacral spina bifida [J]. Mol Neurobiol, 2016. [Epub ahead of print].
[30] Wynshaw-Boris A. Dishevelled: in vivo roles of a multifunctional gene family during development [J]. Curr Top Dev Biol, 2012, 101: 213-235.
[31] Hashimoto M, Shinohara K, Wang J, et al. Planar polarization of node cells determines the rotational axis of node cilia [J]. Nat Cell Biol, 2010, 12(2): 170-176.
[32] Almuedo-Castillo M, Saló E, Adell T. Dishevelled is essential for neural connectivity and planar cell polarity in planarians [J]. Proc Natl Acad Sci U S A, 2011, 108(7): 2813-2818.
[33] Rodriguez-Gil DJ, Hu W, Greer CA. Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals [J]. PLoS One, 2013, 8(2): e56561.
[34] Berwick DC, Harvey K. LRRK2: an éminence grise of Wnt-mediated neurogenesis? [J]. Front Cell Neurosci, 2013, 7: 82.
[35] Dias C, Dietz D, Mazei-Robison M, et al. Dishevelled-2 regulates cocaine-induced structural plasticity and Rac1 activity in the nucleus accumbens [J]. Neurosci Lett, 2015, 598: 23-28.
[36] Ohata S, Nakatani J, Herranz-Perez V, et al. Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus [J]. Neuron, 2014, 83(3): 558-571.
[37] Wu MV, Hen R. The young and the restless: regulation of adult neurogenesis by Wnt signaling [J]. Cell Stem Cell, 2013, 12(2): 139-140.
[38] 李艳菲,孙芳玲,艾厚喜,等. 局灶性脑缺血-再灌注大鼠β-连环蛋白表达的变化[J]. 中国脑血管病杂志, 2014, 11(2): 89-92.
[39] Kuwabara T, Hsieh J, Muotri A, et al. Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis [J]. Nat Neurosci, 2009, 12(9): 1097-1105.
[40] Inestrosa NC, Arenas E. Emerging roles of Wnts in the adult nervous system [J]. Nat Rev Neurosci, 2010, 11(2): 77-86.
[41] Jang MH, Bonaguidi MA, Kitabatake Y, et al. Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis [J]. Cell Stem Cell, 2013, 12(2): 215-223.
[42] 李卓,姜惠丽,刘殿玮,等. Wnt3a在蛛网膜下腔出血后早期脑损伤中对神经发生的作用[J]. 山东大学学报(医学版), 2014, 52(5): 15-19.
[43] Prajerova I, Honsa P, Chvatal A, et al. Distinct effects of sonic hedgehog and Wnt-7a on differentiation of neonatal neural stem/progenitor cells in vitro [J]. Neuroscience, 2010, 171(3): 693-711.
[44] 何倩倩,崔桂云. 蓬乱蛋白在中枢神经系统疾病中的研究进展[J]. 实用医学杂志, 2015, 31(5): 849-851.
[45] Soh UJ, Trejo J. Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds [J]. Proc Natl Acad Sci U S A, 2011, 108(50): E1372-E1380.