Objective To apply the MRI T2 signal intensity of hippocampal subfield in patients with amnestic mild cognitive impairment (aMCI) as early imageology. Methods From October, 2014 to August, 2015, 20 aMCI patients accepted cognitive training (training group), 20 aMCI patients accepted speech communication (speech group), and 20 age- and gender-matched healthy old people (control group) were scanned with MRI using FSE-T2 sequence. The margin of hippocampal subfields were outlined manually for each side to measure the T2 signal intensity. The correlation between hippocampal T2 signal intensity and the scores of Mini-Mental State Examinatlon (MMSE) was analyzed in the training group. Results Before treatment, T2 signal intensity in the bilateral hippocampal head was significantly high in the aMCI patients compared with that in the control group (P<0.05). After treatment, T2 signal intensity in left hippocampal head decreased in the training group compared with that in the speech group (P<0.05), similar to the control group (P>0.05). There was negative correlation between left hippocampal head's T2 signal intensity and the scores of MMSE in the training group before and after treatment (r=-0.61, r=-0.54, P<0.05). Conclusion The T2 signal intensity in left hippocampal head may respond to the cognitive function in patients with aMCI in the early stage, that could be used for diagnosis and evaluation in clinic.
ZHANG Xiao-jie
,
CAO Zhi-hong
,
LUO Yi-feng
,
LIU Yu
,
WU Li-wei
,
SHAN Hai-rong
,
LIU Yi-wen
,
LI Yue-feng
,
WANG Dong-qing
. Application of Hippocampal Subfield Magnetic Resonance Imaging T2 Signal Intensity for Amnestic Mild Cognitive Impairment[J]. Chinese Journal of Rehabilitation Theory and Practice, 2017
, 23(5)
: 575
-579
.
DOI: 10.3969/j.issn.1006-9771.2017.05.018
[1] Albert MS, Dekosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheime's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J]. Alzheimers Dement, 2011, 7(3): 270-279.
[2] Rosenberg PB, Lyketsos C. Mild cognitive impairment: searching for the prodrome of Alzheimer's disease [J]. World Psychiatry, 2008, 7(2): 72-78.
[3] 于洋,尹昌浩. 轻度认知障碍患者脑结构与功能网络变化的研究进展[J]. 中国康复理论与实践. 2015, 21(6): 653-656.
[4] Apostolova LG, Green AE, Babakchanian S, et al. Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer Disease [J]. Alzheimer Dis Assoc Disord, 2012, 26(1): 17-27.
[5] Hanamiya M, Korogi Y, Kakeda S, et al. Partial loss of hippocampal striation in medial temporal lobe epilepsy: pilot evaluation with high-spatial-resolution T 2 -weighted MR imaging at 3.0 T [J]. Radiology, 2009, 251(3): 873-881.
[6] Petersen RC, Smith GE, Waring SC, et al. Mild cognitive impairment: clinical characterization and outcome [J]. Arch Neurol, 1999, 56(3): 303-308.
[7] Gates N, Valenzuela M. Cognitive exercise and its role in cognitive function in older adults [J]. Curr Psychiatry Rep, 2010, 12(1): 20-27.
[8] Martin SB, Smith CD, Collins HR, et al. Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment [J]. Neurobio Aging, 2010, 31(7): 1099-1106.
[9] Malykhin NV, Bouchard TP, Ogilvie CJ, et al. Three-dimensional volumetric analysis and reconstruction of amygdala and hippocampal head, body and tail [J]. Psychiatry Res, 2007, 155(2): 155-165.
[10] Long Z, Jiang YM, Li XR, et al. Vulnerability of welders to manganese exposure–a neuroimaging study [J]. Neurotoxicology, 2014, 45: 285-292.
[11] Sonkusare SK, Kaul CL, Ramarao P. Dementia of Alzheimer's disease and other neurodegenerative disorders–memantine, a new hope [J]. Pharmacol Res, 2005, 51(1): 1-17.
[12] Selkoe DJ. Resolving controversies on the path to Alzheimer's therapeutics [J]. Nat Med, 2011, 17(9): 1060-1065.
[13] Smith AD. Why are drug trials in Alzheimer's disease failing? [J]. Lancet, 2010, 376(9751): 1466.
[14] Zhu WZ, Zhong WD, Wang W, et al. Quantitative MR phase-corrected imaging to investigate increased brain iron deposition of patients with Alzheimer disease [J]. Radiology, 2009, 253(2): 497-504.
[15] House MJ, St PT, Foster JK, et al. Quantitative MR imaging R2 relaxometry in elderly participants reporting memory loss [J]. AJNR Am J Neuroradiol, 2006, 27(2): 430-439.
[16] Schenck JF, Zimmerman EA, Li Z, et al. High-field magnetic resonance imaging of brain iron in Alzheimer disease [J]. Top Magn Reson Imaging, 2006, 17(1): 41-50.
[17] Ramani A, Jensen JH, Helpern JA. Quantitative MR imaging in Alzheimer disease [J]. Radiology, 2006, 241(1): 26-44.
[18] Coan AC, Kobayashi E, Lopes-Cendes I, et al. Abnormalities of hippocampal signal intensity in patients with familial mesial temporal lobe epilepsy [J]. Braz J Med Biol Res, 2004, 37(6): 827-832.
[19] 杜绪仓,王泽忠,鱼博浪. 海马结构的磁共振信号测量[J]. 实用放射学杂志, 2001, 17(5): 336-338.
[20] Fazekas F, Chawluk JB, Alavi A, et al. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging [J]. AJR Am J Roentgenol, 1987, 149(2): 351-356.
[21] Greene SJ, Killiany RJ. Hippocampal subregions are differentially affected in the progression to Alzheimer's disease [J]. Anat Rec (Hoboken), 2012, 295(1): 132-140.
[22] Hanseeuw BJ, Van Leemput K, Kavec M, et al. Mild cognitive impairment: differential atrophy in the hippocampal subfields [J]. Am J Neuroradiol, 2011, 32(9): 1658-1661.
[23] 牛轶瑄,谭纪平,管锦群. 认知训练治疗阿尔茨海默病的疗效观察[J]. 中华物理医学与康复杂志, 2011, 33(1): 52-55.
[24] Kristofikova Z, Stastny F, Bubenikova V, et al. Age- and sex-dependent laterality of rat hippocampal cholinergic system in relation to animal models of neurodevelopmental and neurodegenerative disorders [J]. Neurochem Res, 2004, 29(4): 671-680.
[25] Kristofikova Z, Kozmikova I, Hovorkova P, et al. Lateralization of hippocampal nitric oxide mediator system in people with Alzheimer disease, multi-infarct dementia and schizophrenia [J]. Neurochem Int, 2008, 53(5): 118-125.
[26] Shi F, Liu B, Zhou Y, et al. Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: Meta-analyses of MRI studies [J]. Hippocampus, 2009, 19(11): 1055-1064.
