Objective To investigate the clinical efficacy of Baduanjin combined with biofeedback on functional defecation disorders and the effect on serum brain-gut peptide.Methods From June, 2017 to February, 2018, 68 patients were randomly divided into control group (n=34) and observation group (n=34). Both groups received biofeedback therapy, and the observation group took the training of Baduanjin in addition, for twelve weeks. Then, their overall clinical efficacy, main syndrome score of constipation, the score of Patient Assessment of Constipation Quality of Life (PAC-QOL) and Brain-gut peptide level were compared before and after intervention.Results The total clinical efficacy was higher in the observation group than in the control group (Z=-2.065, P=0.039) without shedding cases. After treatment, the main symptoms of constipation significantly improved (t>2.162, P<0.05) in both groups, while the defecation inactivity, defecation time and abdominal distension score were significantly lower in the observation group than in the control group (t>2.837, P<0.01), as well as the defecation strain (t=-2.070, P<0.05); the score of PAC-QOL decreased (t>2.085, P<0.05) in both groups, and was lower (t=-2.243, P<0.05) in the observation group than in the control group; the level of serum 5-hydroxytryptamine (5-HT), nitric oxide (NO) and vasoactive intestinal peptide (VIP) decreased (t>2.420, P<0.05), while the level of serum substance P (SP) increased (t>6.780, P<0.001), the level of serum 5-HT, serum NO and serum VIP was lower (t>2.039, P<0.05), and the level of serum SP was higher (t=3.500, P<0.001) in the observation group than in the control group.Conclusion Baduanjin combined with biofeedback can improve the clinical efficacy of patients with functional defecation disorders, and its mechanism is closely related to the regulation of abnormal secretion and the expression of brain-gut peptide.
GAO Yuan
,
WANG Jing
,
CHEN Hui
,
WU Jia-yong
,
SHI Jing-yao
,
HUANG Ming-han
. Effect of Baduanjin Combined with Biofeedback on Functional Defecation Disorders and Brain-gut Peptide[J]. Chinese Journal of Rehabilitation Theory and Practice, 2018
, 24(9)
: 1077
-1081
.
DOI: 10.3969/j.issn.1006-9771.2018.09.018
[1] 中华医学会消化病学分会胃肠动力学组. 中国慢性便秘诊治指南(2013,武汉)[J]. 胃肠病学, 2013, 18(10): 605-612.
[2] 王佩佩,罗雯,禹铮,等. 慢性便秘的研究进展[J]. 中国全科医学, 2017, 20(3): 370-373.
[3] 赵劢,谭至柔. 成年人慢性便秘流行病学的研究现状[J]. 世界华人消化杂志, 2014, 22(7): 939-944.
[4] 赵克,尹淑慧. 慢性便秘的诊断方法进展[J]. 中国中西医结合杂志, 2015, 35(4): 503-505.
[5] Lindberg G, Hamid SS, Malfertheiner P, et al.World Gastroenterology Organisation. World Gastroenterology Organisation global guideline: Constipation–a global perspective[J]. J Clin Gastroenterol, 2011, 45(6): 483-487.
[6] 罗云. 生物反馈治疗成人排便障碍型便秘的疗效荟萃分析[D]. 上海:上海交通大学, 2015.
[7] 王建月,丁勇,李云卿. 八段锦对中老年人生理机能影响的Meta分析[J]. 吉首大学学报(自然科学版), 2016, 37(2): 73-77, 82.
[8] 禹方,牛巧能. 健身气功八段锦在中医健康管理应用中的理论探讨[J]. 中国中医药现代远程教育, 2017, 15(22): 488-491.
[9] 赵亚云,焦娟,姜泉. 养生气功八段锦在疾病康复中应用进展[J]. 辽宁中医药大学学报, 2016, 15(12): 109-111.
[10] 郑筱萸. 中药新药临床研究指导原则(试行)[S]. 北京:中国医药科技出版社, 2002: 124-129.
[11] 中华中医药学会脾胃病分会. 便秘中医诊疗专家共识意见(2017)[J]. 中医杂志, 2017, 58(15): 1345-1350.
[12] Satish SCR, Adil EB, Giuseppe C, et al.Anorectal disorders[J]. Gastroenterology, 2016, 150(6): 1430-1442.
[13] Brian EL, Fermin M, Lin C, et al.Bowel disorders[J]. Gastroenterology, 2016, 150(6): 1393-1407.
[14] 古嫚,刘诗. 功能性便秘的研究进展[J]. 临床消化病杂志, 2014, 26(6): 324-325.
[15] 刘洋. 慢性便秘的病因与治疗研究进展[J]. 现代医药卫生, 2014, 30(10): 1496-1499.
[16] Mayer EA, Labus JS, Tillisch K, et al.Towards a systems view of IBS[J]. Nat Rev Gastroenterol Hepatol, 2015, 12(10): 592-605.
[17] Pasricha PJ.Neurogastroenterology: a great career choice for aspiring gastroenterologists thinking about the future[J]. Gastroenterology, 2011, 140(4): 1126-1128.
[18] 宋玉磊,林征,柏亚妹. 功能性便秘疗效评估指标的现状与评价[J]. 中国实用内科杂志, 2016, 36(9): 813-816.
[19] 尹淑慧,赵克. 出口梗阻型便秘的诊治现状[J]. 临床外科杂志, 2018, 26(4): 262-264.
[20] 支晨阳,李为俊,周建华. 出口梗阻型便秘的治疗进展[J]. 中国老年学杂志, 2017, 37(16): 4166-4167.
[21] 赵亚云,焦娟,姜泉. 养生气功八段锦在疾病康复中应用进展[J]. 辽宁中医药大学学报, 2016, 18(12): 109-111.
[22] 连艳玲. 八段锦导引法对疾病治疗作用研究进展[J]. 中西医结合心血管病杂志, 2016, 5(31): 10-11, 13.
[23] 周洪伟,谢琪,刘保延,等. 八段锦对老年人身心健康影响的研究进展[J]. 世界科学技术:中医药现代化, 2016, 18(4): 671-676.
[24] 冯毅挪,卞伯高,潘华山,等. 八段锦运动对老年便秘型肠易激综合征的疗效观察[J]. 体育科研, 2010, 31(2): 89-90, 98.
[25] 孙红梅. 健身气功八段锦练习对老年人肠道菌群的影响[J]. 中国运动医学杂志, 2012, 31(11): 973-977.
