Objective To study the coordination mechanism of brain induced by stimulating on acupoints of different meridians by means of constructing cerebral cortex functional networks reflecting actual brain functional connections. Methods A 128-lead electroencephalogram (EEG) recording and analysis system was used to collect the EEG signals of 14 healthy subjects (eight males and six females) aged 21 to 25 in resting state and magnetic stimulation on the acupuncture points of Guangming (GB37) and Neiguan (PC6) located in different meridians from October to November, 2017. Then EEG sources were localized by group independent component analysis and standard low-resolution brain electromagnetic tomography, and the statistical relationships of EEG components were calculated. Finally, alpha-wave cerebral cortex functional networks were constructed and analyzed based on complex network theory. Results The connections of brain regions associated with movement, vision increased in the stimulation of Guangming acupoint. The brain regions associated with movement, attention and working memory in the stimulation of the Neiguan acupoint were reduced in the network. Some common brain areas were activated and some changes of functional connections were similar. Conclusion The changes in the topological structure of brain networks are basically consistent with the efficacy of the acupuncture point during magnetic stimulation on Guangming and Neiguan of different meridians, however, it causes some similar changes in functional connectivity connections of some brain regions.
[1] Jiang T.Brainnetome: a new-ome to understand the brain and its disorders[J]. Neuroimage, 2013, 80(8): 263-272.
[2] 梁夏,王金辉,贺永. 人脑连接组研究:脑结构网络和脑功能网络[J]. 科学通报, 2010, 55(16): 1565-1583.
[3] 薛明,王江,邓斌,等. 基于广义线性模型的针刺足三里脊髓背根神经活动解码[J]. 物理学报, 2013, 62(9): 491-500.
[4] Pei X, Wang J, Deng B, et al.WLPVG approach to the analysis of EEG-based functional brain network under manual acupuncture[J]. Cogn Neurodyn, 2014, 8(5): 417-428.
[5] Yi GS, Wang J, Han CX, et al.The modulation of brain functional connectivity with manual acupuncture in healthy subjects:An electroencephalograph case study[J]. Chin Phys B, 2013, 22(2): 554-562.
[6] 孙传铸,白丽君,牛璇,等. 基于格兰杰因果分析的针刺不同效应阶段中枢神经传导通路研究[J]. 磁共振成像, 2014, 5(6): 423-429.
[7] 尹宁,徐桂芝,于洪丽,等. 磁刺激穴位对大脑功能网络的影响[J]. 中国生物医学工程学报, 2013, 32(2): 184-190.
[8] 郭磊,陈云阁,王瑶,等. 基于C0复杂度的磁刺激内关穴的脑功能网络构建与分析[J]. 电工技术学报, 2017, 32(12): 155-163.
[9] 邢阳阳,耿跃华,张欣,等. 磁刺激光明穴的脑电响应的脑功能网络构建与分析[J]. 中国生物医学工程学报, 2016, 35(6): 684-690.
[10] 尹宁,徐桂芝,周茜. 磁刺激穴位复杂脑功能网络构建与分析[J]. 物理学报, 2013, 62(11): 569-576.
[11] 郭磊,王瑶,于洪丽,等. 基于近似熵的磁刺激穴位脑功能网络构建与分析[J]. 电工技术学报, 2015, 30(10): 31-38.
[12] Chen JL, Ros T, Gruzelier JH.Dynamic changes of ICA-derived EEG functional connectivity in the resting state[J]. Hum Brain Mapp, 2013, 34(4): 852-868.
[13] 钟治平,吴珊珊,刘波,等. 针刺同一解剖节段不同经络穴位的脑功能磁共振成像研究[J]. 南方医科大学学报, 2010, 30(6): 1363-1365.
[14] 鲁娜,单保慈. 同一经络上穴位的脑功能磁共振成像研究[J]. 中国医学物理学杂志, 2010, 27(3): 1916-1920.
[15] 李国艳,李霞,李淑琴,等. 穴位特异性研究进展[J]. 上海针灸杂志, 2016, 35(4): 383-387.
[16] 梁繁荣,赵凌. 经穴特异性研究进展[J]. 天津中医药, 2014, 31(10): 577-582.
[17] 田宝凤,周媛媛,王悦,等. 基于独立成分分析的全波核磁共振信号噪声滤除方法研究[J]. 物理学报, 2015, 64(22): 446-457.
[18] Schmithorst VJ, Holland SK.Comparison of three methods for generating group statistical inferences from independent component analysis of functional magnetic resonance imaging data[J]. J Magn Reson Imaging, 2004, 19(3): 365-368.
[19] 杨剑,陈书燊,皇甫浩然,等. 静息态脑电信号动态功能连接分析[J]. 物理学报, 2015, 64(5): 382-391.
[20] 李健,陈国镇,陈春晓. 基于脑电信号溯源分析的观看3D电视导致大脑疲劳研究[J]. 中国生物医学工程学报, 2017, 36(1): 46-52.
[21] 葛书慧,裴景春. 光明穴的定位主治及机理考释[J]. 实用中医内科杂志, 2009, 23(2): 37-38.
[22] 周全,高鹏,赵仓焕,等. 视觉刺激状态下正常成人电针光明穴的脑功能性磁共振研究[J]. 中国病理生理杂志, 2010, 26(5): 907-911.
[23] 管永清,杨新治. 电针刺激视觉相关穴位光明穴的脑BOLD-fMRI研究[J]. 河北中医, 2008, 30(10): 1065-1068.
[24] 王虹. 籍针刺络穴的fMRI对中医表里关系的研究——以光明穴与蠡沟穴为例探讨胆经和肝经的表里关系[D]. 武汉:湖北中医药大学, 2012.
[25] 李文文. 基于磁刺激内关穴的诱发脑电源定位分析[D]. 天津, 河北工业大学, 2010.
[26] 陈鹏,赵百孝,秦伟,等. 针刺大陵穴对大脑皮质的影响——MRI研究[J]. 中国针灸, 2008, 28(6): 429-432.
[27] 付平,贾建平,朱江,等. 针刺内关穴对机体不同功能状态下fMRI脑功能成像的影响[J]. 中国针灸, 2005, 25(11): 784-786.
[28] Choi MH, Kim HS, Baek JH, et al.Differences in activation area within brodmann area 2 caused by pressure stimuli on fingers and joints[J]. Medicine (Baltimore), 2015, 94(38): e1657.
[29] 石文英,李平,娄必丹,等. 观察电针健康受试者不同经穴对Resting-state fMRI脑功能连接的影响[J]. 中华中医药学刊, 2017, 35(12): 3029-3032.
[30] 涂燊,赵光,曹晓君,等. 脑网络研究述评[J]. 心理学进展, 2013, 3(6): 277-283.
