Advance in Role of IκB Kinase beta in Inflammatory Response Mechanism post Spinal Cord Injury (review)

  • TANG Rui-ling ,
  • LI Min ,
  • WANG Jun-yu ,
  • XIANG Wu ,
  • ZHANG An-ren
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  • 1.Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610037, China;
    2.Department of Rehabilitation Medicine, the General Hospital of Western Theater Command, Chengdu, Sichuan 610083, China

Received date: 2019-04-15

  Revised date: 2019-05-16

  Online published: 2019-06-25

Supported by

National Natural Science Foundation of China (General) (No. 81674044)

Abstract

IκB kinase beta (IKKbeta) is a key kinase in nuclear factor kappa B (NF-kappaB) signaling pathway. After spinal cord injury, IKKbeta is activated, and the signal pathway of NF-kappa B is abnormally activated, which produces a large number of inflammatory factors, which has a negative impact on the recovery of spinal cord injury. This article mainly summarized the structure and function of IKKbeta and its application in inflammatory reaction after spinal cord injury, trying to find a new target for the treatment of spinal cord injury.

Cite this article

TANG Rui-ling , LI Min , WANG Jun-yu , XIANG Wu , ZHANG An-ren . Advance in Role of IκB Kinase beta in Inflammatory Response Mechanism post Spinal Cord Injury (review)[J]. Chinese Journal of Rehabilitation Theory and Practice, 2019 , 25(6) : 634 -637 . DOI: 10.3969/j.issn.1006-9771.2019.06.003

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