功能性近红外光谱技术在利手、非利手主动抓握-释放任务下脑区激活研究中的应用

doi:10.3969/j.issn.1006-9771.2021.09.010

《中国康复理论与实践》 ›› 2021, Vol. 27 ›› Issue (9): 1066-1071.doi: 10.3969/j.issn.1006-9771.2021.09.010

功能性近红外光谱技术在利手、非利手主动抓握-释放任务下脑区激活研究中的应用

李晁金子^1a,黄富表^1b,杜晓霞^1a,张豪杰¹,张通^1a()

1.首都医科大学康复医学院,北京市 100068
2.中国康复研究中心北京博爱医院,a.神经康复科;b. 作业疗法科,北京市 100068

收稿日期:2021-04-30 修回日期:2021-06-18 出版日期:2021-09-25 发布日期:2021-10-09
通讯作者: 张通 E-mail:tom611@126.com
作者简介:李晁金子(1986-),女,汉族,陕西西安市人,硕士,主治医师,主要研究方向：神经康复。
基金资助:
中国康复研究中心科研项目(2020-Q4)

Application of Functional Near-infrared Spectroscopy in Brain Area Activation Research: Dominant and Non-dominant Hand under Active Grasp-release Task

LI Chao-jin-zi^1a,HUANG Fu-biao^1b,DU Xiao-xia^1a,ZHANG Hao-jie¹,ZHANG Tong^1a()

1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
2. a. Department of Neurological Rehabilitation; b. Department of Occupational Therapy, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China

Received:2021-04-30 Revised:2021-06-18 Published:2021-09-25 Online:2021-10-09
Contact: ZHANG Tong E-mail:tom611@126.com
Supported by:
China Rehabilitation Research Center Research Project(2020-Q4)

摘要/Abstract

摘要：

目的探讨功能性近红外光谱技术(fNIRS)观察健康人利手、非利手复杂运动模式下双侧感觉运动区(SMC)、运动前区(PMC)激活模式中的应用价值。方法 2019年8月至12月,社区招募右利手健康人15例,采用Block设计,执行抓握-释放握力器任务,于双侧SMC、PMC和前额叶皮质行fNIRS探测,根据氧合血红蛋白和脱氧血红蛋白浓度变化观察两种运动状态下脑区激活通道及强度。结果根据氧合血红蛋白浓度,右(利)手运动时,双侧激活通道数相同,左侧SMC激活平均β值更高(P < 0.05);左(非利)手运动时,对侧激活通道更多,右侧SMC激活平均β值更高(P < 0.05)。根据脱氧血红蛋白浓度,利手或非利手运动时,对侧激活通道更多;右(利)手运动时,左侧SMC激活平均β值更高(P < 0.05),通道12 (左侧PMC)和通道26 (右侧PMC)激活更强(P < 0.05)。结论 fNIRS可用于利手、非利手复杂运动模式下手运动相关脑区激活的研究,应更关注氧合血红蛋白浓度变化的结果。

关键词: 功能性近红外光谱, 上肢, 运动功能, 感觉运动区, 运动前区

Abstract:

Objective To apply functional near-infrared spectroscopy (fNIRS) to analyze brain activity pattern of bilateral sensorimotor cortex (SMC) and premotor cortex (PMC) during complex dominant and non-dominant hand movement in healthy subjects.Methods From August to December, 2019, 15 right-handed healthy residents were recruited. The block designed grip-release task was used in the subjects, and detected oxyhemoglobin and deoxyhemoglobin concentration with fNIRS to analyze the activation of bilateral SMC, PMC and prefontal cortex in term of activation channels and intensity.Results For the oxyhemoglobin concentration, the number of activated channels was the same in both hemispheres during right (dominant) hand movement, and the activation of left SMC was stronger (P < 0.05); however, more channels were activated in the right hemisphere during left (non-dominant) hand movement, and the activation of right SMC was stronger (P < 0.05). For the deoxyhemoglobin concentration, more channels were activated in the contralateral hemisphere during either dominant or non-dominant hand movement, and the activation of left SMC, Channel 12 (left PMC) and Channel 26 (right PMC) were stronger during right (dominant) hand movement (P < 0.05).Conclusion It is feasible to use fNIRS to study the activation of hand movement related brain regions during complex movement of dominant and non-dominant hand, especially with the results of oxyhemoglobin concentration.

Key words: functional near-infrared spectroscopy, upper extremity, motor function, sensorimotor cortex, premotor cortex

李晁金子,黄富表,杜晓霞,张豪杰,张通. 功能性近红外光谱技术在利手、非利手主动抓握-释放任务下脑区激活研究中的应用[J]. 《中国康复理论与实践》, 2021, 27(9): 1066-1071.

LI Chao-jin-zi,HUANG Fu-biao,DU Xiao-xia,ZHANG Hao-jie,ZHANG Tong. Application of Functional Near-infrared Spectroscopy in Brain Area Activation Research: Dominant and Non-dominant Hand under Active Grasp-release Task[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(9): 1066-1071.

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通道	脑区	左手任务	右手任务	P值
4	左SMC	2.230	3.340	0.038
5		2.520	4.860	0.004
8		2.480	4.420	0.002
9		2.640	5.000	0.003
平均		2.468	4.405	0.002
12	左PMC	2.440	4.160	0.026
13	左PMC	2.410	3.450	0.014
平均		2.425	3.805	0.160
29	右SMC	2.790	2.220	0.046
32		3.201	2.220	0.013
36		2.910	2.120	0.023
平均		2.967	2.187	0.003

通道	脑区	左手任务	右手任务	P值
1	左侧SMC	0.423	0.972	0.009
4		0.588	0.988	0.045
5		0.635	1.770	0.006
8		0.462	1.290	0.005
9		0.752	1.690	0.004
平均		0.572	1.342	0.003
12	左PMC	2.440	4.160	0.026
26	右PMC	2.410	3.450	0.014
32	右SMC	1.130	5.430	0.004
36		1.050	0.425	0.003
48		0.282	-0.394	0.025
平均		0.821	1.820	0.191

功能性近红外光谱技术在利手、非利手主动抓握-释放任务下脑区激活研究中的应用

Application of Functional Near-infrared Spectroscopy in Brain Area Activation Research: Dominant and Non-dominant Hand under Active Grasp-release Task

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