近五年失神经肌萎缩相关研究的可视化分析

doi:10.3969/j.issn.1006-9771.2022.04.005

《中国康复理论与实践》 ›› 2022, Vol. 28 ›› Issue (4): 399-406.doi: 10.3969/j.issn.1006-9771.2022.04.005

• 专题肌力对姿势稳定影响的研究 • 上一篇下一篇

近五年失神经肌萎缩相关研究的可视化分析

张世雯¹,支金草¹,黄美灵¹,裴飞²,王艳²()

1.黑龙江中医药大学,黑龙江哈尔滨市 150040
2.黑龙江中医药大学附属第二医院,黑龙江哈尔滨市 150001

收稿日期:2021-12-22 修回日期:2022-02-14 出版日期:2022-04-25 发布日期:2022-05-05
通讯作者: 王艳 E-mail:swallow-1113@163.com
作者简介:张世雯(1999-),女,汉族,黑龙江依兰县人,硕士研究生,主要研究方向：周围神经损伤康复。
基金资助:
国家自然科学基金面上项目(81973926);黑龙江省自然科学基金项目(LH2021H090);黑龙江中医药大学"优秀创新人才支持计划"科研项目(2018RCL10)

Visualized analysis of researches on denervated muscle atrophy in the past five years

ZHANG Shiwen¹,ZHI Jincao¹,HUANG Meiling¹,PEI Fei²,WANG Yan²()

1. Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China
2. Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, China

Received:2021-12-22 Revised:2022-02-14 Published:2022-04-25 Online:2022-05-05
Contact: WANG Yan E-mail:swallow-1113@163.com
Supported by:
National Nature Science Foundation of China (General)(81973926);Nature Science Foundation of Heilongjiang Province(LH2021H090);Heilongjiang University of Chinese Medicine "Outstanding Innovative Talents Support Program" Research Project(2018RCL10)

摘要/Abstract

摘要：

目的对近5年失神经肌萎缩相关研究的现状、热点及前沿进行可视化分析。方法利用Web of Science核心数据库检索失神经肌萎缩领域相关文献,通过CiteSpace 5.8.R3软件分别从年发文量、被引频次、国家、机构、作者、关键词、参考文献等方面进行可视化分析。结果 2017年至2021年共检索到516篇文献。年发文量总体呈上升趋势,被引频次逐年增加。美国、加拿大及英国为高影响力国家,意大利帕多瓦大学为领先机构,作者孙华林发文量最多,作者Bodine S C和Sandri M为主要影响人物。基于细胞学、分子生物学和组织形态学的生理病理机制,以及物理因子疗法、药物、运动锻炼等防治措施,是该领域的研究热点。预测以活性氧为靶点,以寻找多靶向蛋白水解系统药物为目标,探究有效的失神经肌萎缩防治措施,可能成为前沿趋势。结论该可视化分析总结了失神经肌萎缩领域研究趋势和发展,并预测潜在的研究前沿和热点方向。

关键词: 失神经支配, 肌肉萎缩, CiteSpace, 可视化分析

Abstract:

Objective To perform a visualized analysis of the current status, hotspots and frontiers of research on denervated muscle atrophy in the past five years.Methods The Web of Science core database was used to retrieve relevant documents in the field of denervated muscle atrophy, and visualized analysis was performed on CiteSpace 5.8.R3 in terms of annual number of published papers, frequency of citations, countries, institutions, authors, keywords and references.Results A total of 516 articles were retrieved from 2017 to 2021. The annual number of published papers was on the rise, and the number of citations was increasing year by year. The United States, Canada and England were high-influence countries, the University of Padua in Italy was the leading institution. The author SUN Hualin published the most articles. The authors Bodine S C and Sandri M were the main influencers. Physiological and pathological mechanisms based on cytology, molecular biology and tissue morphology, as well as prevention and treatment measures based on physical factor therapy, drugs and exercise were the research hotspots in this field. It might be coming that taking reactive oxygen species as the target and looking for multi-targeted proteolytic system drugs as the goal for prevention and treatment.Conclusion This visualized analysis has comprehensively summarized the trends and development of denervated muscle atrophy research, and identified the potential research frontiers and hot directions in the near future.

Key words: denervation, muscle atrophy, CiteSpace, visualized analysis

张世雯,支金草,黄美灵,裴飞,王艳. 近五年失神经肌萎缩相关研究的可视化分析[J]. 《中国康复理论与实践》, 2022, 28(4): 399-406.

ZHANG Shiwen,ZHI Jincao,HUANG Meiling,PEI Fei,WANG Yan. Visualized analysis of researches on denervated muscle atrophy in the past five years[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(4): 399-406.

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参考文献 45

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分类号	大小	轮廓值	关键词
0	19	0.939	肌肉萎缩;蛋白质合成;泛素连接酶;骨骼肌;泛素-蛋白酶体系统
1	19	0.795	肌萎缩侧索硬化症;基因治疗;小鼠模型;机制;儿童
2	18	0.814	吸烟;雷帕霉素的哺乳动物靶点;骨骼肌;线粒体;肌萎缩侧索硬化症
3	16	0.885	人类;神经肌肉接头;脊髓性肌萎缩;失神经萎缩;突变
4	15	0.788	氧化应激;年龄;肥胖;运动锻炼;运动神经
5	15	0.954	脊髓损伤;失神经肌肉退行性变;皮肤活检;纤维;家庭功能性电刺激
6	12	0.951	骨骼肌萎缩;分子机制;微阵列;细胞;萎缩素第一型基因

序号	频次	作者	期刊	参考文献
1	27	Cohen S	Nature Reviews Drug Discovery	Muscle wasting in disease: molecular mechanisms and promising therapies
2	26	Bodine S C	American Journal of Physiology-Endocrinology and Metabolism	Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1
3	20	Milan G	Nature Communications	Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy

序号	中心性	作者	期刊	参考文献
1	0.31	He Q R	Experimental and Therapeutic Medicine	MicroRNA-351 inhibits denervation-induced muscle atrophy by targeting TRAF6
2	0.18	Carnio S	Cell Reports	Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging
3	0.16	Karam C	Skeletal Muscle	Absence of physiological Ca²⁺ transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation

近五年失神经肌萎缩相关研究的可视化分析

Visualized analysis of researches on denervated muscle atrophy in the past five years

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序号	发文量	作者	被引频次	作者
1	12	孙华林	119	Bodine S C
2	9	Sandra Zampieri	99	Sandri M
3	8	朱建伟	73	Schiaffino S
4	8	Holly Van Remmen	52	Cohen S
5	8	丁飞	45	Bonaldo P

序号	频次	关键词	中心性	关键词
1	167	skeletal muscle	0.33	activation
2	87	atrophy	0.3	mouse model
3	77	expression	0.28	functional recovery
4	77	denervation	0.26	regeneration
5	72	muscle atrophy	0.25	mechanism
6	49	neuromuscular junction	0.25	children
7	41	regeneration	0.22	protein
8	38	mechanism	0.22	in vivo
9	38	oxidative stress	0.21	autophagy
10	36	activation	0.21	inflammation

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