《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (5): 423-425.

• 论文 • 上一篇    下一篇

轻、中度疼痛对第一、第二躯体感觉皮质激活的功能磁共振成像研究

公维义1a，薛蕴菁1b，宋施委1c，张良成1a，苏建生1a，范崇玖1a   

  1. 1.福建医科大学附属协和医院，a.麻醉科；b.核磁共振室；c.神经外科，福建福州市 350001。
  • 收稿日期:2011-11-16 修回日期:1900-01-01 出版日期:2012-05-25 发布日期:2012-05-25

Primary and Secondary Somatosensory Cortex Activation Induced by Mild and Moderate Pain: A Functional Magnetic ResonanceImaging Study

GONG Wei-yi, XUE Yun-jing, SONG Shi-wei, et al.   

  1. Department of Anesthesiology, Union Hospital of Fujian Medicine University, Fuzhou 350001, Fujian, China
  • Received:2011-11-16 Revised:1900-01-01 Published:2012-05-25 Online:2012-05-25

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被引次数

6

摘要： 目的研究轻、中度疼痛电刺激对第一躯体感觉皮质(SⅠ)和第二躯体感觉皮质(SⅡ)的激活规律。方法对7 名右利手健康志愿者右足测定痛觉阈值后，给予痛觉阈值和2 倍痛觉阈值刺激，进行视觉模拟评分(VAS)和疼痛分级，行功能磁共振成像。结果痛觉阈值和2 倍痛觉阈值刺激分别引起志愿者轻度疼痛和中度疼痛；两种刺激均可激活SⅠ和SⅡ，并以左侧为主。其中，轻度疼痛主要激活左侧SⅠ，对两侧SⅡ激活区域小；中度疼痛明显激活左侧SⅠ和双侧SⅡ。结论SⅠ对轻、中度疼痛电刺激反应一致，但SⅡ对中度疼痛电刺激的反应更为明显。

关键词: 疼痛, 电刺激, 躯体感觉皮质, 功能磁共振成像

Abstract: Objective To explore the activation of the primary somatosensory cortex (SⅠ) and secondary somatosensory cortex (SⅡ) undermild and moderate pain. Methods 7 healthy right-handed volunteers accepted electrostimulation of 1 and 2 times pain threshold respectively.The severity of pain was determined with the Visual Analogue Score (VAS), and they received functional magnetic resonance imaging(fMRI) simultaneously. Results 1 and 2 times pain threshold electrical stimulation caused mild and moderate pain respectively. Bothmild and moderate pain activated contralateral SⅠ similarly, and bilateral SⅡ with pain intensity. Conclusion SⅠ and SⅡ respond to the mildand moderate pain in different ways.

Key words: pain, electrostimulation, somatosensory cortex, functional magnetic resonance imaging