《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (04): 324-326.

• 基础研究 • 上一篇    下一篇

卡莫司汀-聚乳酸缓释膜片植入家犬脑内的药代动力学研究

卜国云1;王金环2a;杨忠旭1;徐新女2a;刘宏胜2a;王文治2b   

  1. 1. 天津市第四中心医院神经外科，天津市 300140;2. 天津市第一中心医院a.卫生部急救医学重点实验室;b.神经外科，天津市 300192
  • 收稿日期:2008-12-24 出版日期:2009-04-01 发布日期:2009-04-01
  • 通讯作者: 王金环

Pharmacokinetics of BCNU-PLA Delayed Release Wafer Embedded in Brain of Dogs

BU Guo-yun, WANG Jin-huan, YANG Zhong-xu, et al   

  1. The Department of Neurosurgery, the 4th Center Hospital of Tianjin City, Tianjin 300140, China
  • Received:2008-12-24 Published:2009-04-01 Online:2009-04-01

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摘要： 目的 观察卡莫司汀（BCNU）-聚乳酸（PLA）缓释膜片植入家犬脑内的药代动力学特征及BCNU在脑组织中的浓度。方法 制备10%BCNU-PLA缓释膜片，并将其植入12只家犬脑内，术后采集不同时间外周血样并处死家犬采集脑组织，采用高效液相色谱法测定血药浓度和脑组织药物浓度。结果 术后22 h家犬血中可测到BCNU，35 h达到峰值(平均243.64 ng/ml)。术后5 d脑组织中药物浓度平均26.60 μg/g。结论 BCNU-PLA缓释膜片是治疗恶性胶质瘤的一个良好剂型。

关键词: 卡莫司汀-聚乳酸缓释膜片, 高效液相色谱法, 家犬

Abstract: Objective To observe the pharmacokinetics and concentration of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in brain tissue after BCNU-polylactic acid (PLA) delayed release wafer embedded in brain tissues of dogs.Methods 10% BCNU-PLA delayed release wafer were prepared and embedded in brains of 12 dogs. Peripheral blood of dogs was taken and the animals were executed for brain tissue after surgery in different times. BCNU concentrations in blood and brain tissue were quantified by high-performance liquid chromatography.Results BCNU was able to be detected at 22nd hour, and the Cmax (average 243.64 ng/ml) appears at 35th hour after surgery. The average BCNU concentration in brain tissue was 26.60 μg/g at 5th day after surgery.Conclusion BCNU-PLA delayed release wafer is a useful type for treatment of malignant gliocoma.

Key words: 3-bis(2-chloroethyl)-1-nitrosourea-polylactic acid (BCNU-PLA) delayed release wafer, high-performance liquid chromatography, dog