《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (05): 347-348.

• 基础研究 • 上一篇    下一篇

游泳增强川芎嗪对慢性低氧豚鼠耳蜗微循环障碍的治疗作用

史艳莉1; 黄元汛1; 魏劲波2; 段小洪1   

  1. 1.湖北大学体育学院 湖北武汉市 430062;2.武汉科技大学中南分校 湖北武汉市 430070
  • 收稿日期:2004-11-01 出版日期:2005-05-25 发布日期:2005-05-25

Swimming training facilitate the improvement of microcirculations in cochlea after chronic hypoxia with ligustrazine in guinea pigs

SHI Yan-li,HUANG Yuan-xun,WEI Jing-bo,et al   

  1. College of Physical Education, Hubei University,Wuhan 430062,Hubei,China
  • Received:2004-11-01 Published:2005-05-25 Online:2005-05-25

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摘要： 目的观察游泳锻炼对慢性低氧豚鼠耳蜗微循环的影响。方法将28只豚鼠随机分成舱外正常对照组(A组,5只)与慢性低氧模型组(B)。4周后,慢性低氧模型组又随机分为低氧对照组(B1组,5只)、低氧药物(川芎嗪)治疗组(B2 组,8只)和低氧药物治疗配合游泳锻炼组(B3组,10只)。豚鼠喂养8周后,用激光多普勒(LDF)统计耳蜗血流量(CBF),用螺旋韧带铺片光镜观察豚鼠血管纹毛细血管的形态及血管内红细胞计数。结果A组CBF为(98.075±5.08)%,B1组为(86.80±2.12)%(P<0.01);B2组CBF为(89.14±4.12)%,与B1组有显著性差异(P<0.05);B3组CBF为(91.18±5.02)%,与B2组无显著性差异(P>0.05),但与B1组有非常显著性差异(P<0.01)。结论游泳锻炼能促进川芎嗪改善慢性低氧环境下豚鼠耳蜗毛细血管的肿胀及红细胞淤滞现象。

关键词: 慢性缺氧, 耳蜗, 微循环, 川芎嗪, 游泳

Abstract: ObjectiveTo explore the effect of the swimming training on the microcirculations in cochlea in guinea pigs after chronic hypoxia.Methods28 guinea pigs were divided into normal control group (group A) which were outside of cabin and chronic hypoxia model group (group B) randomly. 4 weeks after, the model group were divided into the model control group (group B1), medical treatment group (group B2) and swimming training with medical treatment group (group B3). The blood flow of the cochlea (CBF) were measured using laser Doppler flow. The spiral ligament spreaded-slice optical lens was used to observe the vascular veins, capillary appearance and red blood cells (RBC) counts.Resultsthe CBF of group A was(98.075±5.08)% ,while that of group B1 was(86.80±2.12)%(P<0.01 vs group A), that of group B2 was (89.14±4.12)%(P<0.05 vs group B1), that of group B3 was (91.18±5.02)%(P>0.05 vs group B2, but P<0.01 vs group B1).ConclusionSwimming training can facilitate the improvement of the swelling on the thin blood vessel and the microcirculation in cochlea under chronic hypoxia environment with ligustrazine in guinea pigs.

Key words: chronic hypoxia, cochlea, microcirculations, ligustrazine, swimming training