《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (07): 543-543.

• 专题 • 上一篇    下一篇

不同剂量尿激酶治疗急性脑梗死的临床观察

滕清平; 李琰; 陈玮   

  1. 1.兰州市第一人民医院急诊科 甘肃兰州市 730050;2.兰州市第一人民医院心脑科 甘肃兰州市 730050
  • 收稿日期:2005-01-13 出版日期:2005-07-25 发布日期:2005-07-25

Effect and safety of urokinase in different dosage on acute cerebral infarctions

TENG Qing-ping, LI Yan, CHEN Wei   

  1. Department of Emergency, The First People's Hospital of Lanzhou City, Lanzhou 730050,Gansu ,china
  • Received:2005-01-13 Published:2005-07-25 Online:2005-07-25

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被引次数

13

摘要： 目的观察两种剂量尿激酶对急性脑梗死静脉溶栓的疗效及安全性。方法符合标准的80例急性脑梗死患者随机分成2组:A组接受尿激酶7.5×105U,30min滴完,B组接受尿激酶1.0×106～1.5×106U,30～45min滴完。结果两组治疗后神经功能缺损评分较治疗前均有明显改善,组间比较无显著差异(P>0.05);A组总有效率及显效率分别为82.5%、60.0%;B组分别为87.5%、65.0%(P>0.05)。B组较A组发生出血并发症多。结论小剂量尿激酶静脉溶栓治疗急性脑梗死有效,且更安全。

关键词: 急性脑梗死, 尿激酶, 溶栓治疗

Abstract: ObjectiveTo search for the effect and safety of urokinase (UK) in different dosage on acute cerebral infarction.Methods80 patients suffering from acute cerebral infarction were randomly divided into two groups. Group A received UK 0.75 MU intravenously within 30 min. Group B received UK 1.0～1.5 MU intravenously within 30～45 min. ResultsThe neurological deficits scores was improved in both groups. There was no significant difference between group A and group B(P>0.05). The total effective rate and significant effective rate was 82.5% and 60.0% in group A respectively, but those were 87.5% and 65.0% in group B respectively(P>0.05). More hemorrhage happened in group B. ConclusionThe UK in small dosage is effective and relatively safe in treatment of acute cerebral infarctions.

Key words: acute cerebral infarction, urokinase, thrombolysis