《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (07): 569-570.

• 临床观察 • 上一篇    下一篇

Isaacs综合征

殷宇慧; 高枫   

  1. 北京大学第一医院神经内科 北京市 100034
  • 收稿日期:2005-03-25 出版日期:2005-07-25 发布日期:2005-07-25

Isaacs syndrome:a case report

YIN Yui-hui,GAO Feng   

  1. Department of Neurology, Peking University First Hospital,Beijing 100034, China
  • Received:2005-03-25 Published:2005-07-25 Online:2005-07-25

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摘要： 目的探讨Isaacs综合征的临床特点及发病机制。方法报道1例Isaacs综合征患者。结果和结论Isaacs综合征以全身肌肉均可累及的持续性自发性肌肉痉挛、强直、僵硬和放松困难;;休息和睡眠时症状不消失为特点;;表现为肌纤维颤搐及肌束颤动。Isaacs综合征是一种针对电压门控钾离子通道抗体介导的自身免疫性疾病。

关键词: Isaacs综合征, 肌纤维颤搐, 肌束颤动

Abstract: ObjectiveTo analyze the clinical features and pathogenesis mechanism of Isaacs syndrome.MethodsA case with Isaacs syndrome was reporttedResults and ConclusionIsaacs syndrome is characterized by the occurrence of spontaneous and continuous muscle fiber activity, associated with muscle cramps, pseudomyotonia and myokymia, stiffness and delayed relaxation of the muscle. The stiffness and myokymia are present at rest and during sleep. Isaacs syndrome has been recently suggested to be produced through an immune-mediated mechanism in which voltage-gated potassium channels may be targeted by auto-antibodies.

Key words: Isaacs syndrome, pseudomyotonia, myokymia, voltage-gated potassium channels