《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (12): 1143-1145.

• 综述 • 上一篇    下一篇

针灸治疗脑缺血炎症反应的新靶点—PPAR-γ

刘喆; 刘佩; 朱永旺; 方剑乔   

  1. 浙江中医药大学第三临床医学院,浙江杭州市 310053
  • 收稿日期:2008-07-07 出版日期:2008-12-01 发布日期:2008-12-01

PPAR-γ:A New Target of Treatment for Inflammatory Reaction after Cerebral Ischemic by Acupuncture(review)

LIU Zhe, LIU Pei, ZHU Yong-wang, et al   

  1. The Third Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China
  • Received:2008-07-07 Published:2008-12-01 Online:2008-12-01

PDF (PC)

被引次数

14

摘要： 脑缺血后的炎症反应可加重神经损伤,激活过氧化物酶体增殖物激活受体γ(PPAR-γ)可抑制脑缺血后炎症反应,发挥神经保护作用,被视为缺血性卒中治疗新的药理作用靶点;针灸可通过抑制炎症细胞因子的合成、下调炎症介质及黏附分子的表达、抑制炎症细胞的功能等多种途径干预脑缺血后炎症反应,发挥脑保护作用。因此,筛选有效激发PPAR-γ活化的针灸方法,从PPAR-γ活化途径研究针灸治疗脑缺血炎症反应的作用机制,将是一个大有希望的研究方向。

关键词: 脑缺血, 炎症反应, 过氧化物酶体增殖物激活受体γ(PPAR-γ), 针灸, 综述

Abstract: The inflammatory reaction after acute cerebral infarction can aggravate the cerebral ischemic reperfusion injury.Activation of peroxisome proliferator-activated receptors-γ(PPAR-γ) has neuroprotective effects by which induces anti-inflammatory actions in cerebral ischaemia,thus as a potential novel pharmacological target for ischemic stroke was regarded.Acupuncture can improve cerebral ischemia injury by inhibiting synthesis of inflammatory cytokines,downregulating expressions of inflammatory mediators and adhesion molecule,suppressing the functions of inflammatory cells.Therefore,it will be a promising orientation to sift the effective acupuncture for that can stimulate the activation of PPAR-γ,and the research of mechanism of acupuncture on anti-inflammatory reaction after cerebral ischemic by activating PPAR-γ dependent pathways.

Key words: cerebral ischemia, inflammatory reaction, peroxisome proliferator-activated receptors-γ(PPAR-γ), acupuncture, review