《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (11): 897-898.

• 专题 • 上一篇    下一篇

逼尿肌A型肉毒毒素重复注射治疗脊髓损伤后逼尿肌反射亢进及神经源性尿失禁

李东; 廖利民; 熊宗胜; 付光; 鞠彦合; 吴娟; 韩春生; 史文博; 黄悦   

  1. 北京博爱医院泌尿外科 北京市 100068
  • 收稿日期:2005-10-08 出版日期:2005-11-25 发布日期:2005-11-25

Botulinum toxin type A repeated injections into detrusor to treat detrusor hyperreflexia and neurogenic incontinence in spinal cord injury patients: 6 cases report

LI Dong, LIAO Li-min, XIONG Zong-sheng, et al   

  1. Department of Urology, BeijingCharity Hospital,Beijing 100068, China
  • Received:2005-10-08 Published:2005-11-25 Online:2005-11-25

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摘要： 目的评价经尿道膀胱壁逼尿肌A型肉毒毒素重复注射治疗脊髓损伤患者逼尿肌反射亢进和神经源性尿失禁的临床效果。方法损伤平面在骶髓以上的完全性脊髓损伤患者6例,均有单侧或双侧肾积水,严重尿失禁,口服抗胆碱药物治疗效果不理想。将300 U A型肉毒毒素经膀胱镜注射针分30个点注射于除膀胱颈和三角区以外的膀胱壁。重复注射3次。治疗前后行影像尿动力学检查,并记录排尿日记,观察毒副作用。结果重复注射3次平均起效时间10.5 d(5～21 d),3次注射间隔时间分别平均为8.9个月和5.8个月。第1次注射后平均尿失禁次数由10.1/d降至3.3/d,平均导尿量由98.5 ml/次增至404.2 ml/次,平均最大膀胱测压容积由95.4 ml增至385.6 ml,平均充盈末逼尿肌压力由105.8 cmH2O降至31 cmH2O。第2次注射后平均尿失禁次数由9.7/d降至3.7/d,平均导尿量由108.3 ml/次增至387.2 ml/次,平均最大膀胱测压容积由105.4 ml增至375.6 ml,平均充盈末逼尿肌压力由97.8 cmH2O降至33 cmH2O。第3次注射后平均尿失禁次数由9.2/d降至3.9/d,平均导尿量由115.7 ml/次增至363.9 ml/次,平均最大膀胱测压容积由102 ml增至357.6 ml,平均充盈末逼尿肌压力由98.1cmH2O降至36.9cmH2O。随访6个月,未观察到明显毒副作用。结论逼尿肌A型肉毒毒素重复注射是治疗脊髓损伤患者逼尿肌反射亢进和神经源性尿失禁的一种有效、安全的微创方法。

关键词: A型肉毒毒素, 逼尿肌反射亢进, 神经源性尿失禁, 脊髓损伤

Abstract: ObjectiveTo evaluate the effects of Botulinum toxin type A(BTX-A) repeated injection into detrusor to treat detrusor hyperreflexia and neurogenic incontinence in spinal cord injury(SCI) patients.Methods6 patients with SCI were included into the study.300 U of BTX-A was dissolved in saline 15 ml,and injected into 30 different sites in detrusor using a flexible cystoscopic needle.BTX-A injection was repeated 3 times for all the patients.Urodynamic examination,voiding diary and toxic effects were recorded.ResultsThe improvement for symptoms was observed within 5 to 21 days.The effects of injections lasted averagely 8.9 and 5.8 months for each injection.After the first injection,the mean frequency of incontinence decreased from 10.1 /d to 3.3 /d.The mean volume of intermittent catheterization(IC) increased from 98.5 ml to 404.2 ml each time.Mean cystometric volume increased from 95.4 ml to 385.6 ml,mean maximum storage detrusor pressure decreased from 105.8 cmH2O to 31 cmH2O.After the second injection,the mean frequency of incontinence decreased from 9.7/d to 3.7/d.The mean volume of IC increased from 108.3 ml to 387.2 ml each time.Mean cystometric bladder storage volume increased from 105.4 ml to 375.6 ml.Mean maximum storage detrusor pressure decreased from 97.8 cmH2O to 33 cmH2O.After the third injection,the mean frequency of incontinence decreased from 9.2/d to 3.9/d.The mean volume of IC increased from 115.7 ml to 363.9 ml each time.Mean cystometric volume increased from 102 ml to 357.6 ml.Mean maximum storage detrusor pressure decreased from 98.1 cmH2O to 36.9 cmH2O.The patients were followed up for 6 months.No adverse and toxic effect was observed.ConclusionBotulinum toxin type A repeated injection into detrusor is effective,safe,feasible and mini-invasive to treat detrusor hyperreflexia and neurogenic incontinence in patients with SCI.Botulinum toxin type A repeated injection into detrusor is effective,safe,feasible and mini-invasive to treat detrusor hyperreflexia and neurogenic incontinence in patients with SCI.

Key words: Botulinum toxin type A, detrusor hyperreflexia, incontinence, spinal cord injury