《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (01): 37-38.

• 基础研究 • 上一篇    下一篇

TL-Ⅰ号方镇痛作用的实验研究

赵永烈1; 王玉来2; 高颖3; 王爱成1; 刘子旺1   

  1. 1.北京中医药大学 北京市 100029;2.北京中医药大学附属东方医院 北京市 100078;3.北京中医药大学附属东直门医院脑病重点实验室 北京市 100700
  • 收稿日期:2005-09-26 出版日期:2006-01-25 发布日期:2006-01-25

Analgesic effect of TL-Ⅰ prescription

ZHAO Yong-lie, WANG Yu-lai, GAO Ying, et al   

  1. Beijing University of Traditional Chinese Medicine, Beijing 100029, China
  • Received:2005-09-26 Published:2006-01-25 Online:2006-01-25

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被引次数

34

摘要： 目的研究TL-Ⅰ号药方的镇痛作用。方法健康ICR小鼠随机分为6组:阴性对照组、阳性对照组、通天组、大剂量组、中剂量组、小剂量组。用热板致痛实验和醋酸扭体实验测定小鼠的痛阈值。结果TL-Ⅰ号方对小鼠热板致痛的痛阈值有一定程度的提高;对小鼠醋酸致痛引起的扭体次数有降低作用,高剂量组的痛阈值有明显的提高;扭体次数有明显的降低。结论TL-Ⅰ号方具有明显的镇痛作用。

关键词: 镇痛, 热板法, 醋酸扭体法, TL-Ⅰ号方

Abstract: ObjectiveTo investigate the analgesic effect of TL-Ⅰ prescription.MethodsHealth ICR mouses were randomly divided into 6 groups: negative control group, positive control group, Tongtian group, large doses group,middle doses group and small doses group. The pain threshold of mouses were detected with hot plate and acetic acid writhing.ResultsTL-Ⅰ prescription can raise the threshold of pain induced by hot plate and reduce the numbers of writhing induced by acetic acid in mice, which was more significant in large doses group. ConclusionTL-Ⅰ prescription can be an effective analgesic.

Key words: analgesia, hot plate test, acetic acid writhing test, TL-Ⅰ prescription