《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (04): 309-310.

• 基础研究 • 上一篇    下一篇

TL-Ⅰ号方镇静作用的实验研究

赵永烈1a; 王玉来2; 高颖1b; 刘子旺1a; 王爱成2   

  1. 1.北京中医药大学 a.中医内科;b.神经内科 北京市 100029;2.北京中医药大学东方医院 北京市 100078
  • 收稿日期:2006-02-06 出版日期:2006-04-25 发布日期:2006-04-25

Empirical Study of Sedative Effect of TL-Ⅰ Prescription in Rat

ZHAO Yong-lie, WANG Yu-lai, GAO Ying, et al   

  1. The Department of Internal Medicine of TCM, Beijing University of TCM, Beijing 100029, China
  • Received:2006-02-06 Published:2006-04-25 Online:2006-04-25

PDF (PC)

被引次数

19

摘要： 目的研究TL-Ⅰ号药方的镇静作用。方法72只健康ICR小鼠随机分为正常组、模型组、阳性对照组、大剂量治疗组、中剂量治疗组、小剂量治疗组,用尾悬挂法和动物行为-自发活动分析系统测定偏头痛模型小鼠的活动行为。结果TL-Ⅰ号方能延长偏头痛模型小鼠尾悬挂的静止时间,能使模型小鼠在自主活动箱中的活动路程和活动时间缩短。结论TL-Ⅰ号方具有一定的镇静作用。

关键词: 镇静, 尾悬挂法, 动物行为-自发活动分析, TL-Ⅰ号方

Abstract: ObjectiveTo investigate the sedative effect of TL-Ⅰ prescription.Methods72 healthy ICR mice were randomly divided into 6 groups: normal group, model group, positive control group, large doses Chinese materia medica group, middle doses Chinese materia medica group and small doses Chinese materia medica group. The active behavior of migraine-model-mouse was detected with tail suspension test and the analytical system of animal behavior-spontaneous movement.ResultsTL-Ⅰ prescription could prolong the quiescent time of migraine-model-mouse and shorten the active journey and time in the autonomic active box of migraine-model-mouse.ConclusionTL-Ⅰ prescription has sedative effect.

Key words: sedation, mouse tail suspension test, analytical system of animal behavior-spontaneous movement, TL-Ⅰ prescription