《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (05): 369-371.

• 专题 •    下一篇

高压氧对大鼠脊髓损伤后内源性神经干细胞的诱导作用

刘海; 王忠诚; 安沂华; 崔勇; 晋强   

  1. 北京市神经外科研究所 北京市 100050
  • 收稿日期:2005-12-30 出版日期:2006-05-25 发布日期:2006-05-25

Induction of Endogenous Neural Stem Cells with Hyperbaric Oxygen after Half Cut-off of Spinal Cord in Rats

LIU Hai,WANG Zhong-cheng,AN Yi-hua,et al   

  1. Beijing Institute of Neurosugery, Beijing 100050, China
  • Received:2005-12-30 Published:2006-05-25 Online:2006-05-25

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摘要： 目的探讨高压氧对脊髓损伤后内源性干细胞的诱导修复。方法脊髓半横断后高压氧治疗,进行行为学评分、电镜及免疫组化检查。结果内源性神经干细胞治疗后较对照组增多。结论高压氧使实验动物内源性神经干细胞增殖、分化加强,脊髓损伤后的功能得到改善。

关键词: 脊髓损伤, 高压氧, 内源性神经干细胞, 大鼠

Abstract: ObjectiveTo investigate the effect of hyperbaric oxygen (HBO) on proliferation and differentiation of endogenous neural stem cells after acute spinal cord half cut-off in rats. MethodsThe differences of proliferation and differentiation of endogenous neural stem cells between injured group and intervention group were compared. ResultsThere were remarkable differences between injured group and intervention group. ConclusionHBO can promote the proliferation and differentiation of the neural stem cells in rats after spine cord injury.

Key words: spinal cord injuries, hyperbaric oxygen, endogenous neural stem cells, rats