关键词: 逼尿肌过度活动症, 尿失禁, 脊髓损伤, 最大膀胱容量, 曲司氯铵, 综述

Abstract: Trospium chloride is an anticholinergic agent with predominantly peripheral nonselective antimuscarinic activity and water solubility. It has potential therapeutic value in decreasing detrusor contracivity and tonity, so as to increase predominantly mean maximal bladder capacity and compliance. Multicenter studys showed that the tolerability and efficacy of trospium chloride was as same as oxybutynin and better than toterodine. Adverse events of trospium chloride is the same as other anticholinergic agents, however its specially constitutional feature so as not to have toxicity to central nervous system. Trospium chloride has potential therapeutic value in the neurourological rehabilitation.

Key words: overactive bladder, incontinence, spinal cord injury, maximal bladder capacity, trospium chloride, review