《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (3): 201-204.

• 论文 •    下一篇

抑制脊髓损伤后星形胶质细胞增殖和胶质瘢痕形成的研究进展

武亮1,2，李建军1,2，陈亮1,2，远丽1,2，逯晓蕾1,2   

  1. 1.中国康复研究中心北京博爱医院脊柱脊髓神经功能重建科，北京市 100068；2.首都医科大学康复医学院，北京市 100068。
  • 收稿日期:2010-01-25 修回日期:1900-01-01 出版日期:2010-03-25 发布日期:2010-03-25
  • 通讯作者: 李建军

Astrocyte Proliferation and Glial Scar Formation after Spinal Cord Injury (review)

WU Liang, LI Jian-jun, CHEN Liang, et al.   

  1. Department of Spinal Cord Function Reconstruction, Capital Medical University School of Rehabilitation Medicine, Beijing Charity Hospital, China Rehabilitation Research Centre, Beijing 100068, China
  • Received:2010-01-25 Revised:1900-01-01 Published:2010-03-25 Online:2010-03-25

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摘要： 对星形胶质细胞（AS）的性质和功能、脊髓损伤后的AS病理变化和作用、抑制AS增殖和胶质瘢痕形成的实验方法等方面进行综述。认为，AS激活后的不同分化时期对脊髓损伤修复具有一定的积极作用；但成熟以后，AS可以分泌有害因子，形成化学性胶质屏障，严重影响神经再生和阻碍轴突延长。脊髓损伤后AS被激活，静止态、活化态和增殖态往往并存，形成原因复杂，目前采取单一的方法很难有效控制AS增殖和胶质瘢痕形成。

关键词: 脊髓损伤（SCI）, 星形胶质细胞（AS）, 胶质瘢痕, 胶质纤维酸性蛋白（GFAP）, 综述

Abstract: The nature and functions of astrocytes (AS)， the pathological changes and roles of AS after spinal cord injury， the experimental methods of inhibiting AS proliferation and glial scar formation， and so on, were reviewed. AS beneficially affects repairing injured spinal cord at different periods of differentiation. However， adult AS secreting the factors formed the chemical glial barrier which severely affects nerve regeneration and hinders axon extension. Because of the static， activated and proliferative AS tending to coexist after spinal cord injury， and complex factors of barrier formation， the current approach taken by a single method is difficult to effectively control the AS proliferation and glial scar formation.

Key words: spinal cord injury(SCI), astrocytes(AS), glial scar, glial fibrillary acidic protein (GFAP), review