《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (9): 851-852.

• 论文 • 上一篇    下一篇

阿尔茨海默病、血管性痴呆及轻度认知损害患者载脂蛋白E基因多态性分析

石胜良，齐玉晶，叶子明，黄东红，汤媛媛，陆丽萍，全雪梅，李宗亚，秦超，毕桂南   

  1. 广西医科大学第一附属医院神经内科,广西南宁市 530021。
  • 收稿日期:2010-06-24 修回日期:1900-01-01 出版日期:2010-09-25 发布日期:2010-09-25
  • 通讯作者: 毕桂南

Apolipoprotein-E Gene Polymorphism in Patients with Alzheimer's Disease, Vascular Dementia or Mild Cognitive Impairment

SHI Sheng-liang, QI Yu-jing, YE Zi-ming, et al   

  1. Neurology Department of the First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, China
  • Received:2010-06-24 Revised:1900-01-01 Published:2010-09-25 Online:2010-09-25

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摘要： 目的探讨载脂蛋白E（ApoE）基因多态性与阿尔茨海默病（AD）、血管性痴呆（VD）和轻度认知损害（MCI）的关系。方法收集AD、VD及MCI患者外周血检测ApoE基因型，进行χ2检验。结果所有患者中ε3/ε3基因型所占比例最大，未检测到ε2/ε2及ε4/ε4基因型。AD组ε3/ε4基因型（P=0.001）及ε4基因（P=0.013）高于MCI组。VD组ε4基因高于MCI组（P=0.044）。结论ApoE ε4基因与AD的关系最为密切，是AD的危险因素。但其与VD和MCI的关系尚需进一步研究。

关键词: 载脂蛋白E, 基因多态性, 阿尔茨海默病, 血管性痴呆, 轻度认知损害

Abstract: ObjectiveTo explore the Apolipoprotein-E （ApoE） gene polymorphism in patients with Alzheimer's disease （AD）, vascular dementia (VD) or mild cognitive impairment (MCI). MethodsPeripheral blood was taken from patient with AD, VD or MCI to determine the ApoE genotypes. ResultsThe most of the patients were ε3/ε3 genotype, while the ε2/ε2 and ε4/ε4 could not be detected. ε3/ε4 genotype （P=0.001） and ApoE ε4 allele （P=0.013） was more frequent in AD than in MCI. ApoE ε4 was more frequent in VD than in MCI （P=0.044）. ConclusionApoE ε4 allele is a risk factor in AD, and may be associated with VD and MCI.

Key words: Apolipoprotein-E, gene polymorphism, Alzheimer's disease, vascular dementia, mild cognitive impairment