《中国康复理论与实践》

《中国康复理论与实践》 ›› 2002, Vol. 8 ›› Issue (09): 537-538.

• 临床康复 • 上一篇    下一篇

尼莫地平对重型脑损伤患者疗效及预后的影响

张建宏; 范建中; 邓爱文   

  1. 第一军医大学南方医院康复科 广东广州市 510515
  • 收稿日期:2001-11-26 出版日期:2002-09-25 发布日期:2002-09-25

Effect and prognosis of nimodipine on the patients with severe traumatic brain injury

ZHANG Jian-hong, FAN Jian-zhong, DENG Ai-wen   

  1. Department of Rehabilitation Medicine, Nanfang Hospital of the First Military Medicine University, Guangzhou 510515,Guangdong, China
  • Received:2001-11-26 Published:2002-09-25 Online:2002-09-25

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被引次数

2

摘要： 目的探讨尼莫地平对重型颅脑损伤患者疗效及预后的影响。方法64例重型颅脑损伤术后患者分为尼莫地平组32例和常规组32例,治疗前后评定格拉斯哥昏迷量表(GCS),清醒患者评定日常生活活动 (ADL)及认知能力。随访6个月,行格拉斯哥结局量表 (GOS)评定及Barthel指数和简易精神状态检查 (MMSE)评分。结果治疗后两组GCS评分均有明显提高,清醒患者MMSE评分尼莫地平组明显高于常规组。6个月后两组GOS及ADL评分无显著差异,尼莫地平组MMSE评分高于常规组。结论尼莫地平可在颅脑损伤早期促进认知功能的恢复。患者的预后主要取决于脑损害的程度。

关键词: 颅脑损伤, 尼莫地平, 治疗, 预后

Abstract: ObjectiveTo observe the therapeutic effect and prognosis of nimodipine on severe traumatic brain injury. Methods64 patients with severe traumatic brain injury were divided into the nimodipine group(32 cases) and the routine treatment group(32 cases). The Glasgow Coma Scale(GCS) was assessed before and after the treatment. The Activities of Daily Living(ADL) and cognitive ability were evaluated in clear-headed patients. After 6 months follow-up, the Glasgow Outcome Scale (GOS), Bathel index and Mini Mental State Examination (MMSE) score were carried on.ResultsIn both of the two groups, GCS score were increased distinctively after treatment. The MMSE score in nimodipine group was higher than that of routine treatment group. There was no statistic difference in GOS and ADL between two groups after 6 months, but MMSE in nimodipine group was higher than that of routine treatment group. Conclusions Nimodipine could be helpful in cognitive function. The prognosis of severe traumatic brain injury lied on the degree of cerebral damage.

Key words: traumatic brain injury, nimodipine, treatment, prognosis