《中国康复理论与实践》

《中国康复理论与实践》 ›› 2014, Vol. 20 ›› Issue (7): 683-689.

• 论文 • 上一篇    下一篇

肺表面活性物质蛋白基因多态性与慢性阻塞性肺疾病易感性关联的Meta分析

张林，张云，张智峰，张文涵，方春晓，于丽艳   

  1. 1.大连医科大学附属第一医院，a.呼吸内科，b.消化内科，辽宁大连市116011；2.大连大学附属中山医院，辽宁大连市116001。
  • 收稿日期:2013-12-12 修回日期:2014-01-06 出版日期:2014-07-25 发布日期:2014-07-25

Polymorphisms of Surfactant Protein Genes and Chronic Obstructive Pulmonary Disease Risk: A Meta- analysis

ZHANG Lin,ZHANG Yun, ZHANG Zhi-feng, et al.   

  1. Department of Respiratory Medicine, First Affiliated Hospital of Dalian Medical University, Dalian,Liaoning 116011, China
  • Received:2013-12-12 Revised:2014-01-06 Published:2014-07-25 Online:2014-07-25

PDF (PC)

摘要： 目的探讨肺表面活性物质蛋白(SP)相关基因多态性与慢性阻塞性肺疾病(COPD)的关联。方法检索万方数据、维普、Google 学术、PubMed、CNKI、CBM、EMBASE、Web of Science 等电子数据库，检索范围从建库至2013 年9 月，采用Stata12.0 进行Meta分析。结果本研究共计纳入7 项病例对照研究，包括1279 例COPD患者和1482 名健康对照人群。SP-A基因多态性与COPD易感性增加有关(等位基因模型OR=1.53, 95%CI: 1.14~2.05, P=0.005；显性模型OR=1.65, 95%CI: 1.02~2.69, P=0.043；隐性模型OR=1.66, 95%CI: 1.17~2.35, P=0.005；纯合子模型OR=2.06, 95%CI: 1.24~3.41, P=0.005；杂合子模型OR=1.59, 95%CI: 1.13~2.22, P=0.007)，但SP-B和SP-D基因多态性均与COPD易感性关联无统计学意义(均P>0.05)。亚组分析表明，SP-A基因多态性与亚洲人群COPD易感性增加关系密切，但与欧美人群无关。结论SP-A基因多态性可能与亚洲人群COPD易感性增加有关。

关键词: 表面活性物质蛋白, 多态性, 慢性阻塞性肺疾病, Meta分析

Abstract: Objective To evaluate the relationship between polymorphisms in surfactant protein (SP) genes and susceptibility to chronic obstructive pulmonary disease (COPD). Methods An extensive literature search for relevant studies was conducted in databases of Wanfang Data, VIP, Google Scholar, PubMed, CNKI, CBM, EMBASE and Web of Science and so on from inception to Sep., 2013. A meta-analysis was then performed using Stata 12.0 software. Results 7 case-control studies were included with a total of 1,279 COPD cases and 1,482 healthy controls. This meta-analysis revealed that polymorphisms of the SP-A gene might be associated with an increased risk of COPD (allele model: OR=1.53, 95%CI: 1.14~2.05, P=0.005; dominant model: OR=1.65, 95%CI: 1.02~2.69, P=0.043; recessive model: OR=1.66,95%CI: 1.17~2.35, P=0.005: homozygous model: OR=2.06, 95%CI: 1.24~3.41, P=0.005; eterozygous model: OR =1.59, 95%CI: 1.13~2.22, P=0.007; respectively). However, there was no evidence for any association between polymorphisms of the SP-B and SP-D genes and COPD risk (all P>0.05). Further subgroup analysis by ethnicity suggested that SP-A genetic polymorphisms were associated with an increased risk of COPD among Asians, but not among Caucasians. Conclusion SP-A genetic polymorphisms may contribute to increasing susceptibility to COPD, especially among Asians.

Key words: surfactant protein, polymorphism, chronic obstructive pulmonary disease, Meta-analysis