《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (09): 1031-1036.

• 基础研究 • 上一篇    下一篇

弥散张量成像在脊髓损伤临床和基础研究中的应用

刘长彬，李建军，杨德刚，杨明亮，杜良杰，李军，高峰，蒙倩茹，董学超   

  1. 刘长彬(1990-)，男，汉族，山东德州市人，硕士研究生，主要研究方向：脊柱脊髓损伤的康复与治疗。通讯作者：李建军(1962-)，男，汉族，教授，主要研究方向：脊柱脊髓损伤的康复与治疗。E-mail: crrc100@163.com。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-09-25 发布日期:2015-09-25

Application of Diffusion Tensor Imaging in Clinical and Basic Studies of Spinal Cord Injury (review)

LIU Chang- bin, LI Jian- jun, YANG De- gang, YANG Ming- liang, DU Liang- jie, LI Jun, GAO Feng, MENG Qian-ru, DONG Xue-chao   

  1. 1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China; 2. Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-09-25 Online:2015-09-25

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摘要： 弥散张量成像(DTI)技术可以检测脊髓白质中水分子的弥散情况、脊髓纤维束的完整性及损伤后的病理变化。临床上，DTI对急性和慢性脊髓损伤病变都比较敏感，多用于脊髓型颈椎病、多发性硬化症、脊髓损伤后继发性脑损害、脊髓神经根损害等。基础研究，DTI可定量分析损伤脊髓的微观结构变化、病理变化，并可为行为学评估提供有力的辅助诊断依据，主要动物有鼠、猴、牛、猫、猪、犬等。

关键词: 脊髓损伤, 弥散张量成像, 临床, 动物模型, 综述

Abstract: Diffusion tensor imaging (DTI), which responds with the diffusion of water molecules in spinal cord white matter, may be used to detect the integrity of the spinal cord fiber bundles and the pathological changes after injury. It is sensitive in acute and chronic spinal cord injury, such as cervical spondylotic myelopathy, multiple sclerosis, brain damage secondary spinal cord injury, spinal nerve root damage, and so on. In basic studies, DTI can reveal the microstructure and pathological changes of the injured spinal, and be correlated with behavioral assessment, which involved mice, monkeys, calves, cats, swines, dogs, and so on.

Key words: spinal cord injury, diffusion tensor imaging, clinic, animals model, review