《中国康复理论与实践》

《中国康复理论与实践》

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基于线栓法大鼠大脑中动脉闭塞的局灶性脑缺血模型的比较研究①

缪培，张通，米海霞   

  1. 1. 首都医科大学康复医学院，北京市100068；2. 中国康复研究中心北京博爱医院，北京市100068。
  • 出版日期:2016-10-25 发布日期:2016-12-05

Comparative Study of Focal Cerebral Ischemia Model Based on Middle Cerebral Artery Occlusion with Suture- occluded Method in Rats (review)

MIAO Pei, ZHANG Tong, MI Hai-xia   

  1. 1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China; 2. Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
  • Published:2016-10-25 Online:2016-12-05

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摘要： 制备大鼠大脑中动脉闭塞(MCAO)模型的方式有很多，由线栓法制备的大鼠局灶性脑缺血模型目前被公认是较为理想的局灶性脑缺血模型，可用于脑血管疾病的基础与临床研究。但该方法仍存在技术要求高、模型差异性大、动物死亡率高等缺陷。目前不少国内外学者通过改变线栓保留时间、线栓入路、线栓类型及线栓插入深度等制造了多种局灶性脑缺血模型。本文分别对不同的线栓法模型之间以及线栓法和其他造模方式之间进行比较，发现不同的脑缺血模型脑梗死病理生理变化不同，对于大鼠的影响也不同。

关键词: 线栓法, 局灶性脑缺血模型, 大脑中动脉闭塞, 综述

Abstract: There are many ways to prepare middle cerebral artery occlusion (MCAO) rat model. The focal cerebral ischemia model established by the suture-occluded method is widely accepted as an ideal focal cerebral ischemia model, which can be used in the basic and clinical study of cerebral vascular diseases. However, it still has the defects of high technical requirement, large model difference and high animal mortality. A variety of focal cerebral ischemia models were established by changing the retention time of the thread, the road the thread plugging into, the type of thread bolt and the depth of the thread plugging. This article compared different suture-occluded method, as well as the suture-occluded method to other modeling methods, different cerebral ischemia models may be different in the pathophysiology of cerebral infarction, and the effects may also be different.

Key words: suture-occluded method, focal cerebral ischemia model, middle cerebral artery occlusion, review