缺血性脑卒中后小胶质细胞损伤作用的研究进展

doi:10.3969/j.issn.1006-9771.2017.01.010

摘要/Abstract

摘要： 小胶质细胞是脑内固有免疫细胞,激活后分泌的一系列有害物质在缺血性脑卒中后的炎性损伤过程中发挥重要作用,如超氧化物、一氧化氮、基质金属蛋白酶等,其激活机制涉及髓系细胞触发受体1、Toll样受体4、过氧化物酶体增殖物激活受体、嘌呤受体等。小胶质细胞受体的靶向干预可能成为缺血性脑卒中新的干预靶点。

关键词: 缺血性脑卒中, 小胶质细胞, 损伤, 受体, 综述

Abstract: Microglial cells are the resident immune cells of brain. The activated microglia produces a range of deleterious substances, which plays an important role in the inflammation of post-stroke, such as superoxide, nitric oxide, matrix metalloproteinases, etc. The activation of microglia may involve triggering receptor expressed on myeloid cells-1, Toll-like receptors 4, peroxisome proliferator-activated receptors, purinergic receptors, etc. Intervention targeted to microglial receptor is becoming a new strategy for ischemic stroke.

Key words: ischemic stroke, microglia, injury, receptors, review

中图分类号:

R743.3

王栋, 侯博儒, 杨文桢, 康军林, 任海军. 缺血性脑卒中后小胶质细胞损伤作用的研究进展[J]. 《中国康复理论与实践》, 2017, 23(1): 42-45.

WANG Dong, HOU Bo-ru, YANG Wen-zhen, KANG Jun-lin, REN Hai-jun. Role of Microglia in Damage after Ischemic Stroke (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(1): 42-45.

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