微型正电子发射计算机断层显像在脑缺血模型中的应用研究进展

doi:10.3969/j.issn.1006-9771.2017.07.006

摘要/Abstract

摘要： 微型正电子发射计算机断层显像(MicroPET)是专门用于小动物活体实验研究的断层显像技术。它利用放射性核素标记分子进行活体显像,可以从分子水平对神经元的活性进行无创、动态和定量的观测。MicroPET可早期检测动脉粥样斑块,测定脑各局部血流量变化,判断脑缺血区组织存活状态,对疾病危险因素控制、疾病诊断、病程分期及疗效评价等均有重要价值。

关键词: 微型正电子发射计算机断层显像, 脑缺血, 动物模型, 综述

Abstract: Micro positron emission computed tomography (PET) is a sort of tomography technique specifically for small animal studies. It can be used to observe radionuclide labeling molecules in vivo, especially for neuronal activities noninvasively, dynamically and quantitatively at the molecular level. MicroPET can be used for early detection of atherosclerotic plaques, measurement of cerebral blood flow, judgment of the survival status in cerebral ischemia area in animal model. It is important for the control of risk factors, disease diagnosis, disease staging and evaluation of curative effect.

Key words: micro positron emission computed tomography, cerebral ischemia, animal model, review

中图分类号:

R743.3

李莹莹, 白玉龙. 微型正电子发射计算机断层显像在脑缺血模型中的应用研究进展[J]. 《中国康复理论与实践》, 2017, 23(7): 770-774.

LI Ying-ying, BAI Yu-long. Advance of Application of Micro Positron Emission Computed Tomography in Cerebral Ischemia Model (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(7): 770-774.

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