阿尔茨海默病脑内小胶质细胞的极化状态及电针的影响研究进展

doi:10.3969/j.issn.1006-9771.2017.07.008

摘要/Abstract

摘要： 脑内免疫细胞小胶质细胞有两种极化状态M1和M2。M2状态可吞噬β-淀粉样蛋白、防止Tau蛋白过度磷酸化,还可清除部分病理产物。针刺发挥作用的机制可能与转变小胶质细胞的极化状态有关。

Abstract: There are two phenotypes of microglia, M1 and M2. Microglia in M2 polarization may associate with the phagorytosis of beta-amyloid and inhibition of Tau hyperphosphorylation, as well as in other pathology. Electroacupuncture can impact the phenotypes of microglia, which may play a role in the treatment for Alzheimer's disease.

Key words: Alzheimer's disease, microglia, phenotypes, electroacupuncture, review

中图分类号:

R749.1

李珑, 柳维林, 王志福, 陶静, 陈立典. 阿尔茨海默病脑内小胶质细胞的极化状态及电针的影响研究进展[J]. 《中国康复理论与实践》, 2017, 23(7): 779-782.

LI Long, LIU Wei-lin, WANG Zhi-fu, TAO Jing, CHEN Li-dian. Role of Microglia Polarization in Alzheimer's Disease and Association to Electroacupuncture (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(7): 779-782.

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