MicroRNAs与脊髓损伤的研究进展

doi:10.3969/j.issn.1006-9771.2017.10.006

摘要/Abstract

摘要： ] 脊髓损伤是一种严重的中枢神经系统性创伤,导致损伤节段以下运动和感觉功能障碍。治疗脊髓损伤的方法主要围绕恢复继发性损伤和促进再生来开展。microRNAs (miRNAs)在脊髓损伤所导致的继发性损伤和促进再生中扮演着重要角色。本文进一步的阐述不同亚型miRNA在脊髓损伤中所起的作用,同时评价这些miRNA作为脊髓损伤治疗靶点的研究前景。

关键词: microRNA, 脊髓损伤, 诊断, 治疗, 预后, 综述

Abstract: Spine cord injury is a kind of severe central nervous system trauma causing motion and sensation dysfunction. Treatment focuses on controlling secondary injury cascade and improving regeneration which are heavily regulated by microRNAs (miRNAs). This review discussed the effect of miRNAs with different subtypes on spine cord injury, and investigated their potential roles as therapeutic agents in the personalized treatment of patients with spine cord injury.

Key words: microRNA, spine cord injury, diagnosis, treatment, prognosis, review

中图分类号:

R651.2

张政佩, 余铃, 孙祥然, 郭卫春. MicroRNAs与脊髓损伤的研究进展[J]. 《中国康复理论与实践》, 2017, 23(10): 1152-1156.

ZHANG Zheng-pei, YU Ling, SUN Xiang-ran, GUO Wei-chun. Advance of microRNAs for Spine Cord Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(10): 1152-1156.

参考文献

[1] Dumont RJ, Okonkwo DO, Verma S, et al. Acute spinal cord injury, part I: pathophysiologic mechanisms [J]. Clin Neuropharmacol, 2001, 24(5): 254-264. doi:10.1097/00002826-20010 9000-00003.
[2] Bareyre FM, Schwab ME. Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays [J]. Trends Neurosci, 2003, 26(10): 555-563. doi:10.1016/j.tins.2003.08.004.
[3] Di Giovanni S, Knoblach SM, Brandoli C, et al. Gene profiling in spinal cord injury shows role of cell cycle in neuronal death [J]. Ann Neurol, 2003, 53(4): 454-468. doi:10.1002/ana.10472.
[4] Dong J, Lu M, He X, et al. Identifying the role of microRNAsin spinal cord injury [J]. Neurol Sci, 2014, 35(11): 1663-1671. doi:10.1007/s10072-014-1940-0.
[5] Ning B, Gao L, Liu RH, et al. microRNAs in spinalcord injury: potential roles and therapeutic implications [J]. Int J Biol Sci, 2014, 10(9): 997-1006. doi:10.7150/ijbs.9058.
[6] Nieto-Diaz M, Esteban FJ, Reigada D, et al. microRNA dysregulation in spinal cord injury:causes, consequences and therapeutics [J]. Front Cell Neurosci, 2014, 8: 53. doi:10.3389/fncel.2014.00053.
[7] Karimi-Abdolrezaee S, Billakanti R. Reactive astrogliosis after spinal cord injury–beneficial and detrimental effects [J]. Mol Neurobiol, 2012, 46(2): 251-264. doi:10.1007/s12035-012-8287-4.
[8] Sahni V, Mukhopadhyay A, Tysseling V, et al. BMPR1a and BMPR1b signaling exert opposing effects on gliosisafter spinal cord injury [J]. J Neurosci, 2010, 30(5): 1839-1855. doi:10.1523/JNEUROSCI.4459-09.2010.
[9] Wang CY, Yang SH, Tzeng SF. microRNA-145 as one negative regulator of astrogliosis [J]. Glia, 2015, 63(2): 194-205. doi:10.1002/glia.22743.
[10] Strickland ER, Hook MA, Balaraman S, et al. microRNA dysregulation following spinal cord contusion: implications forneural plasticity and repair [J]. Neuroscience, 2011, 186: 146-160. doi:10.1016/j.neuroscience.2011.03.063.
[11] Lee JK, Zheng B. Axon regeneration after spinal cord injury: insight from genetically modified mouse models [J]. Restor Neurol Neurosci, 2008, 26(2-3): 175-182.
[12] Li P, Teng ZQ, Liu CM. Extrinsic and intrinsic regulation of axon regeneration by microRNAs after spinal cord injury [J]. Neural Plast, 2016, 2016: 1279051.
[13] Fiorenza A, Barco A. Role of Dicer and the miRNA system in neuronal plasticity and brain function [J]. Neurobiol Learn Mem, 2016, 135: 3-12. doi:10.1016/j.nlm.2016.05.001.
[14] Fan H, Zhang K, Shan L, et al. Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury [J]. Mol Neurodegener, 2016, 11: 14. doi:10.1186/s13024-016-0081-8.
[15] Sahni V, Mukhopadhyay A, Tysseling V, et al. BMPR1a and BMPR1b signaling exert opposing effects on gliosisafter spinal cord injury [J]. J Neurosci, 2010, 30(5): 1839-1855. doi:10.1523/JNEUROSCI.4459-09.2010.
[16] Hong P, Jiang M, Li H. Functional requirement of dicer1 and miR-17-5pin reactive astrocyte proliferation after spinal cord injury in the mouse [J]. Glia, 2014, 62(12): 2044-2060. doi:10.1002/glia.22725.
[17] Liu NK, Wang XF, Lu QB, et al. Altered microRNA expression following traumatic spinal cord injury [J]. Exp Neurol, 2009, 219(2): 424-429. doi:10.1016/j.expneurol.2009.06.015.
[18] Yunta M, Nieto-Diaz M, Esteban FJ, et al. microRNA dysregulation in the spinal cord following traumatic injury [J]. PLoS One, 2012, 7(4): e34534. doi:10.1371/journal.pone.0034534.
[19] Hu JZ, Huang JH, Zeng L, et al. Anti-apoptotic effect of microRNA-21 after contusion spinal cord injury in rats [J]. J Neurotrauma, 2013, 30(15): 1349-1360. doi:10.1089/neu.2012.2748.
[20] Xu Y, An BY, Xi XB, et al. microRNA-9 controls apoptosis of neurons by targeting monocyte chemotactic protein-induced protein 1 expressionin rat acute spinal cord injury model [J]. Brain Res Bull, 2016, 121: 233-240. doi:10.1016/j.brainresbull.2016.01.011.
[21] Liu D, Huang Y, Jia C, et al. Administration of antagomir-223inhibits apoptosis, promotes angiogenesis and functional recovery in ratswith spinal cord injury [J]. Cell Mol Neurobiol, 2015, 35(4): 483-491. doi:10.1007/s10571-014-0142-x.
[22] Lewen A, Matz P, Chan PH. Free radical pathways in CNS injury [J]. J Neurotrauma, 2000, 17(10): 871-890. doi:10.1089/neu.2000.17.871.
[23] Jiao G, Pan B, Zhou Z, et al. microRNA-21 regulates cellproliferation and apoptosis in H(2)O(2)-stimulated rat spinal cord neurons [J]. Mol Med Rep, 2015, 12(5): 7011-7016. doi:10.3892/mmr.2015.4265.
[24] Jee MK, Jung JS, Im YB, et al. Silencing of miR20a is crucialfor Ngn1-mediated neuroprotection in injured spinal cord [J]. Hum Gene Ther, 2012, 23(5): 508-520. doi:10.1089/hum.2011.121.
[25] Liu XJ, Zheng XP, Zhang R, et al. Combinatorial effects of miR-20a and miR-29b on neuronal apoptosis induced by spinal cord injury [J]. Int J Clin Exp Pathol, 2015, 8(4): 3811-3818.
[26] Alam MM, O'Neill LA. microRNAs and the resolution phase of inflammation in macrophages [J]. Eur J Immunol, 2011, 41(9): 2482-2485. doi:10.1002/eji.201141740.
[27] Hutchison ER, Kawamoto EM, Taub DD, et al. Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes [J]. Glia, 2013, 61(7): 1018-1028. doi:10.1002/glia.22483.
[28] Xie W, Li M, Xu N, et al. miR-181a regulates inflammation responses in monocytes and macrophages [J]. PLoS One, 2013, 8(3): e58639. doi:10.1371/journal.pone.0058639.
[29] Izumi B, Nakasa T, Tanaka N, et al. microRNA-223 expression in neutrophils in the early phase of secondary damage after spinal cord injury [J]. Neurosci Lett, 2011, 492(2): 114-118. doi:10.1016/j.neulet.2011.01.068.
[30] Hu J, Zeng L, Huang J, et al. miR-126 promotes angiogenesis and attenuates inflammation after contusion spinal cord injury in rats [J]. Brain Res, 2015, 1608: 191-202. doi:10.1016/j.brainres.2015.02.036
[31] Ding Y, Kastin AJ, Pan W. Neural plasticity after spinal cord injury [J]. Curr Pharm Des, 2005, 11(11): 1441-1450. doi:10.2174/1381612053507855.
[32] Olde Loohuis NF, Kos A, Martens GJ, et al. microRNA networks direct neuronal development and plasticity [J]. Cell Mol Life Sci, 2012, 69(1): 89-102. doi:10.1007/s00018-011-0788-1.
[33] Xin H, Li Y, Liu Z, et al. miR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles [J]. Stem Cells, 2013, 31(12): 2737-2746. doi:10.1002/stem.1409.
[34] Schratt GM, Tuebing F, Nigh EA, et al. A brain-specific microRNA regulates dendritic spine development [J]. Nature, 2006, 439(7074): 283-289.
[35] Meng Y, Zhang Y, Tregoubov V, et al. Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice [J]. Neuron, 2002, 35(1): 121-133.
[36] Park KK, Liu K, Hu Y, et al. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway [J]. Science, 2008, 322(5903): 963-966. doi:10.1126/science.1161566.
[37] Liu G, Detloff MR, Miller KN, et al. Exercise modulates microRNAs that affect the PTEN/mTOR pathway in rats after spinal cord injury [J]. Exp Neurol, 2012, 233(1): 447-456. doi:10.1016/j.expneurol.2011.11.018.
[38] Letzen BS, Liu C, Thakor NV, et al. microRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cells [J]. PLoS One, 2010, 5(5): e10480. doi:10.1371/journal.pone.0010480.
[39] 陈建敏,杨拯,梁楠,等. 脊髓损伤相关的microRNA研究进展[J]. 中国康复理论与实践, 2013, 19(7): 635-639.
[40] Diaz Quiroz JF, Tsai E, Coyle M, et al. Precise control of miR-125b levels is required to create a regeneration-permissive environment after spinal cord injury: a cross-species comparison between salamander and rat [J]. Dis Model Mech, 2014, 7(6): 601-611. doi:10.1242/dmm.014837
[41] Shin D, Shin JY, McManus MT, et al. Dicer ablation in oligodendrocytes provokes neuronal impairment in mice [J]. Ann Neurol, 2009, 66(6): 843-857. doi:10.1002/ana.21927.
[42] Liu Y, Han N, Li Q, et al. Bioinformatics analysis of microRNA time-course expression in brown rat (Rattus norvegicus): spinal cord injury self-repair [J]. Spine, 2016, 41(2): 97-103. doi:10.1097/BRS.0000000000001323.
[43] Zou D, Chen Y, Han Y, et al. Overexpression of microRNA-124 promotes the neuronal differentiation of bone marrow-derived mesenchymal stem cells [J]. Neural Regen Res, 2014, 9(12): 1241-1248. doi:10.4103/1673-5374.135333.
[44] Zhao Y, Jiang H, Liu XW, et al. miR-124 promotes bone marrow mesenchymal stem cells differentiation into neurogenic cells for accelerating recovery in the spinal cord injury [J]. Tissue Cell, 2015, 47(2): 140-146. doi:10.1016/j.tice.2015.01.007.
[45] Zhao Y, Zhang H, Zhang D, et al. Loss of microRNA-124 expression in neurons in the peri-lesion area in mice with spinal cord injury [J]. Neural Regen Res, 2015, 10(7): 1147-1152. doi:10.4103/1673-5374.156983.
[46] Shi X, Yan C, Liu B, et al. miR-381 regulates neural stem cell proliferation and differentiation via regulating Hes1 expression [J]. PLoS One, 2015, 10(10): e0138973. doi:10.1371/journal.pone.0138973.