双侧颈总动脉结扎致血管性痴呆大鼠模型研究进展

doi:10.3969/j.issn.1006-9771.2018.03.012

《中国康复理论与实践》 ›› 2018, Vol. 24 ›› Issue (3): 309-312.doi: 10.3969/j.issn.1006-9771.2018.03.012

双侧颈总动脉结扎致血管性痴呆大鼠模型研究进展

孟敏, 李林

首都医科大学宣武医院药物研究室,北京市神经药物工程技术研究中心,神经变性病教育部重点实验室,北京市 100053

收稿日期:2017-11-08 修回日期:2018-01-24 出版日期:2018-03-25 发布日期:2018-03-27
通讯作者: 李林。E-mail: linlixw@126.com
作者简介:孟敏(1993-),女,汉族,北京市人,硕士研究生,主要研究方向：药理学。通讯作者：李林,教授,主要研究方向：神经药理学。
基金资助:
1.北京市科技计划项目(No. Z131102002813066; No. D0206001043191); 2.北京市高层次卫生技术人才计划(No. 2011-1-7)

Progress in Vascular Dementia Rat Model Induced by Bilateral Common Carotid Artery Ligation (review)

MENG Min, LI Lin

Department of Pharmacology, Xuanwu Hospital, Capital Medical University; Beijing Engineering Research Center for Nervous System Drugs; Key Laboratory for Neurodegenerative Disease of Ministry of Education, Beijing 100053, China

Received:2017-11-08 Revised:2018-01-24 Published:2018-03-25 Online:2018-03-27
Contact: LI Lin. E-mail: linlixw@126.com
Supported by:
Supported by　Beijing Research and Development Plan (No. Z131102002813066; No. D0206001043191) and Beijing Health High Level Professional Plan (No. 2011-1-7)

摘要/Abstract

摘要： 大鼠施行永久性双侧颈总动脉结扎手术后,出现脑血流量减少、学习和记忆功能障碍、脑内神经元损伤及死亡、突触及树突损伤,以及神经炎症反应等的时程变化,能复制人类血管性痴呆的病理改变和临床症状,为血管性痴呆的病理机制和防治药物研究提供帮助。

关键词: 血管性痴呆, 双侧颈总动脉结扎, 认知功能, 神经元, 突触, 神经炎症, 大鼠, 综述

Abstract: Rats after permanent bilateral common carotid artery ligation would result in cerebral blood flow reduction, learning and memory dysfunction, neuronal injury and death, synaptic and dendritic injury, and neuroinflammation, etc., which reproduce the pathology and clinical symptoms of human vascular dementia, that help for further research on pathophysiology and treatment of vascular dementia.

Key words: vascular dementia, bilateral common carotid artery ligation, cognitive function, neuron, synapse, neuroinflammation, rats, review

中图分类号:

R749.1

孟敏, 李林. 双侧颈总动脉结扎致血管性痴呆大鼠模型研究进展[J]. 《中国康复理论与实践》, 2018, 24(3): 309-312.

MENG Min, LI Lin. Progress in Vascular Dementia Rat Model Induced by Bilateral Common Carotid Artery Ligation (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(3): 309-312.

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双侧颈总动脉结扎致血管性痴呆大鼠模型研究进展

Progress in Vascular Dementia Rat Model Induced by Bilateral Common Carotid Artery Ligation (review)

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