儿茶酚胺氧位甲基转移酶基因Val158Met多态性与帕金森病抑郁的相关性

doi:10.3969/j.issn.1006-9771.2018.07.001

《中国康复理论与实践》 ›› 2018, Vol. 24 ›› Issue (7): 753-756.doi: 10.3969/j.issn.1006-9771.2018.07.001

儿茶酚胺氧位甲基转移酶基因Val158Met多态性与帕金森病抑郁的相关性

马惠姿¹, 马凌燕¹, 冯涛^{1, 2, 3}

1.首都医科大学附属北京天坛医院神经病学中心神经变性病科,北京市 100050;
2.国家神经系统疾病临床医学研究中心,北京市 100050;
3.北京脑重大疾病研究院帕金森病研究所,北京市 100050

收稿日期:2018-05-09 修回日期:2018-07-09 出版日期:2018-07-25 发布日期:2018-08-01
通讯作者: 冯涛。E-mail: happyft@sina.com
作者简介:马惠姿(1962-),女,汉族,北京市人,硕士,副主任医师,主要研究方向：帕金森病、焦虑抑郁及运动障碍病等。通讯作者：冯涛,男,博士,主任医师。
基金资助:
1.脑重大疾病数据的采集规范及挖掘分析研究(一期)(No. Z151100003915117); 2.北京市自然科学基金项目(No. 7164254); 3.国家自然科学基金面上项目(No. 81571226; No. 81771367); 4.首都特色临床应用研究(No.Z171100001017041); 5.北京市科委基金项目(No. Z151100003915150); 6.“十三五”国家重点研发计划(No. 2016YFC1306501)

Relationship between Val158Met Polymorphism in Catechol-O-methyltransferase Gene and Depression in Parkinson's Disease

MA Hui-zi¹, MA Ling-yan¹, FENG Tao^{1, 2, 3}

1. Center for Neurodegenerative Disease, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;
2. China National Clinical Research Center for Neurological Disease, Beijing 100050, China;
3. Parkinson's Disease Center, Beijing Institute for Brain Disorder, Capital Medical University, Beijing 100050, China

Received:2018-05-09 Revised:2018-07-09 Published:2018-07-25 Online:2018-08-01
Contact: FENG Tao. E-mail: happyft@sina.com
Supported by:
Supported by Data Collection and Mining for Major Brain Diseases (No. Z151100003915117), Beijing Natural Science Foundation (No. 7164254), National Natural Science Foundation of China (General) (No. 81571226 and No. 81771367), Capital Clinical Application Research Program (No. Z171100001017041), Beijing Science and Technology Commission Fund (No. Z151100003915150) and National Key Research and Development Program of the 13th Five-Year Plan (No. 2016YFC1306501)

摘要/Abstract

摘要： 目的探讨儿茶酚胺氧位甲基转移酶(COMT)基因Val158Met多态性与中国帕金森病抑郁的相关性。方法 2016年6月至2017年12月,散发帕金森病患者268例,根据汉密尔顿抑郁量表评定结果分为抑郁组(n=116)和非抑郁组(n=152)。同时招募252例既往健康,无神经系统疾病,性别、年龄与患者相匹配的健康体检者作为对照组。两组留取外周血,提取基因组DNA。采用限制性片段长度多态性-聚合酶链反应(PCR-RELP)和限制性酶切,分析COMT基因Val158Met多态性。结果抑郁组、非抑郁组、对照组在COMT基因Val158Met位点基因型(χ²=0.78, P>0.05)、等位基因 (χ²=0.25, P>0.05)分布均无显著性差异。结论 COMT基因Val158Met多态性并非中国帕金森病抑郁人群的遗传易感因素。

关键词: 帕金森病, 抑郁, 儿茶酚胺氧位甲基转移酶, Val158Met, 多态性

Abstract: Objective To explore the relationship between the polymorphism of catechol-O-methyltransferase (COMT) gene Val158Met site and depression in Parkinson's disease. Methods From June, 2016 to December, 2017, a cohort of 268 Chinese patients with Parkinson's disease and 252 age- and gender-matched healthy control subjects were recruited. The patients were divided into depression group (n=116) and non-depression group (n=152) according to Hamilton Depression Scale score. Their blood samples were collected and the polymorphism of Val158Met was carried out using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results No difference was identified in Val158Met polymorphism of genotype (χ²=0.78, P>0.05) and allele (χ²=0.25, P>0.05) among the depression group, the non-depression group and the control group. Conclusion The polymorphism of Val158Met in COMT gene does not contribute to the risk of depression in Parkinson's disease in China.

Key words: Parkinson's disease, depression, catechol-O-methyltransferase, Val158Met, polymorphism

中图分类号:

R742.5

马惠姿, 马凌燕, 冯涛. 儿茶酚胺氧位甲基转移酶基因Val158Met多态性与帕金森病抑郁的相关性[J]. 《中国康复理论与实践》, 2018, 24(7): 753-756.

MA Hui-zi, MA Ling-yan, FENG Tao. Relationship between Val158Met Polymorphism in Catechol-O-methyltransferase Gene and Depression in Parkinson's Disease[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(7): 753-756.

参考文献

[1] Zhang ZX, Roman GC, Hong Z, et al.Parkinson's disease in China: prevalence in Beijing, Xi'an, and Shanghai[J]. Lancet, 2005, 365(9459): 595-597.
[2] Reijnders JS, Ehrt U, Weber WE, et al.A systematic review of prevalence studies of depression in Parkinson's disease[J]. Mov Disord, 2008, 23(2): 183-189, 313.
[3] Zhuo C, Xue R, Luo L, et al.Efficacy of antidepressive medication for depression in Parkinson disease: a network meta-analysis[J]. Medicine (Baltimore), 2017, 96(22): e6698.
[4] Aarsland D, Påhlhagen S, Ballard CG, et al.Depression in Parkinson disease–epidemiology, mechanisms and management[J]. Nat Rev Neurol, 2011, 8(1): 35-47.
[5] Sheikh HI, Kryski KR, Smith HJ, et al.Catechol-O-methyltransferase gene val158met polymorphism and depressive symptoms during early childhood[J]. Am J Med Genet B Neuropsychiatr Genet, 2013, 162B(3): 245-252.
[6] Cao C, Wang L, Wang R, et al.The COMT gene variant is associated with depression's decreased positive affect symptoms in Chinese adults[J]. Psych J, 2014, 3(4): 264-272.
[7] Alvim-Soares A, Miranda D, Campos SB, et al.Postpartum depression symptoms associated with Val158Met COMT polymorphism[J]. Arch Womens Ment Health, 2013, 16(4): 339-340.
[8] Fernández-de-Las-Peñas C, Ambite-Quesada S, Gil-Crujera A, et al. Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depression, and disability, but not pressure pain sensitivity, in women with fibromyalgia syndrome[J]. J Pain, 2012, 13(11): 1068-1074.
[9] Danzi BA, La Greca AM.Genetic pathways to posttraumatic stress disorder and depression in children: Investigation of catechol-O-methyltransferase (COMT) Val158Met using different PTSD diagnostic models[J]. J Psychiatr Res, 2018, 102: 81-86.
[10] Antypa N, Drago A, Serretti A.The role of COMT gene variants in depression: Bridging neuropsychological, behavioral and clinical phenotypes[J]. Neurosci Biobehav Rev, 2013, 37(8): 1597-1610.
[11] Lin Z, He H, Zhang C, et al.Influence of Val108/158Met COMT gene polymorphism on the efficacy of modified electroconvulsive therapy in patients with treatment resistant depression[J]. Cell Biochem Biophys, 2015, 71(3): 1387-1393.
[12] Chiesa A, Lia L, Alberti S, et al.Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients with major depression[J]. Int J Psychiatry Clin Pract, 2014, 18(2): 97-102.
[13] Asarnow LD, Thompson RJ, Joormann J, et al.Children at risk for depression: memory biases, self-schemas, and genotypic variation[J]. J Affect Disord, 2014, 159: 66-72.
[14] Myrga JM, Juengst SB, Failla MD, et al.COMT and ANKK1 genetics interact with depression to influence behavior following severe TBI: an initial assessment[J]. Neurorehabil Neural Repair, 2016, 30(10): 920-930.
[15] Goenjian AK, Noble EP, Steinberg AM, et al.Association of COMT and TPH-2 genes with DSM-5 based PTSD symptoms[J]. J Affect Disord, 2015, 172: 472-478.
[16] Minassian A, Young JW, Geyer MA, et al.The COMT Val158Met polymorphism and exploratory behavior in bipolar mania[J]. Mol Neuropsychiatry, 2018, 3(3): 151-156.
[17] Saravani R, Galavi HR, Lotfian SM. Catechol-O-Methyltransferase (COMT) gene (Val158Met) and brain-derived neurotropic factor (BDNF) (Val66Met) genes polymorphism in schizophrenia: a case-control study[J]. Iran J Psychiatry, 2017, 12(4): 265-270.
[18] TSJ V, de Jong L, Schäfer AT, et al. The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: a transdiagnostic meta-analysis[J]. PLoS One, 2018, 13(2): e0192658.
[19] Lodhi RJ, Wang Y, Rossolatos D, et al.Investigation of the COMT Val158Met variant association with age of onset of psychosis, adjusting for cannabis use[J]. Brain Behav, 2017, 7(11): e00850.
[20] Debost JC, Debost M, Grove J, et al.COMT Val158Met and MTHFR C677T moderate risk of schizophrenia in response to childhood adversity[J]. Acta Psychiatr Scand, 2017, 136(1): 85-95.
[21] Chaudhuri KR, Healy DG, Schapira AH.Non-motor symptoms of Parkinson's disease: diagnosis and management[J]. Lancet Neurol, 2006, 5(3): 235-245.
[22] Goodarzi Z, Ismail Z.A practical approach to detection and treatment of depression in Parkinson disease and dementia[J]. Neurol Clin Pract, 2017, 7(2): 128-140.
[23] Goodarzi Z, Mrklas KJ, Roberts DJ, et al.Detecting depression in Parkinson disease: a systematic review and meta-analysis[J]. Neurology, 2016, 87(4): 426-437.
[24] Xie CL, Chen J, Wang XD, et al.Repetitive transcranial magnetic stimulation (rTMS) for the treatment of depression in Parkinson disease: a meta-analysis of randomized controlled clinical trials[J]. Neurol Sci, 2015, 36(10): 1751-1761.
[25] 高力舒, 谢健. COMT基因多态性的研究进展[J]. 国际精神病学杂志, 2010, 37(4): 212-215.

儿茶酚胺氧位甲基转移酶基因Val158Met多态性与帕金森病抑郁的相关性

Relationship between Val158Met Polymorphism in Catechol-O-methyltransferase Gene and Depression in Parkinson's Disease

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