脊髓损伤的代谢组学研究进展

doi:10.3969/j.issn.1006-9771.2018.08.007

《中国康复理论与实践》 ›› 2018, Vol. 24 ›› Issue (8): 904-908.doi: 10.3969/j.issn.1006-9771.2018.08.007

脊髓损伤的代谢组学研究进展

杨新乐¹, 王明¹, 杨成伟², 徐雅洁³, 甄平²

1.兰州大学第二医院,甘肃兰州市 730000;
2.兰州军区兰州总医院全军骨科中心,甘肃兰州市 730050;
3河南省荣军医院,河南新乡市 453000

收稿日期:2018-05-10 修回日期:2018-05-31 出版日期:2018-08-25 发布日期:2018-08-20
通讯作者: 甄平。E-mail: zhenpingok@163.com
作者简介:杨新乐(1992-),男,满族,河南洛阳市人,硕士研究生,主要研究方向：脊柱脊髓损伤。通讯作者：甄平,男,主任医师,教授,硕士研究生导师,主要研究方向：骨与关节损伤。
基金资助:
1.国家自然科学基金项目(No. 81601905); 2.中国博士后科学基金项目(No. 2017M623433)

Advance in Metabolomics of Spinal Cord Injury (review)

YANG Xin-le¹, WANG Ming¹, YANG Cheng-wei², XU Ya-jie³, ZHEN Ping²

1. The Second Hospital of Lanzhou University, Lanzhou, Gansu 730000, China;
2. Department of Orthopaedic, the Lanzhou General Hospital of PLA, Lanzhou, Gansu 730050, China;
3. Henan Rong Jun Hospital, Xinxiang, Henan 453000, China

Received:2018-05-10 Revised:2018-05-31 Published:2018-08-25 Online:2018-08-20
Contact: ZHEN Ping. E-mail: zhenpingok@163.com
Supported by:
Supported by National Natural Science Foundation of China (No. 81601905) and China Postdoctoral Science Foundation (No. 2017M623433)

摘要/Abstract

摘要： 脊髓损伤常导致机体不同程度的感觉及运动功能障碍,造成永久残疾,且并发症多,难以治愈。代谢组学作为一种新发展的技术,通过分析个体应激后代谢物的变化,找出用于辅助诊断、治疗或判断预后的特异性生物标志物,能够在疾病早期为患者制定最佳的治疗及康复方案。目前已有相关研究在脊髓损伤的诊断、治疗和预后监测等方面取得一定成果,鉴别了一些具有潜在价值的生物标志物,但脊髓损伤后的病理生理机制尚不完全清楚,相关生物标志物也缺少临床试验的验证。

关键词: 脊髓损伤, 代谢组学, 生物标志物, 综述

Abstract: Spinal cord injury (SCI) often causes different degrees of sensory and motor dysfunction, resulting in permanent disability, with many complications and difficult to cure. Metabolomics, as a new developing technique, identifies specific biomarkers for diagnosis, treatment or prognosis judgement by analyzing the changes in the metabolites after individual stress, and can make the best treatment and rehabilitation program for the patients in the early stage of the disease. At present, some achievements have been made in the diagnosis, treatment and prognosis monitoring of spinal cord injury, and some potential biomarkers have been identified. However, the pathophysiology of spinal cord injury is not fully understood, and relevant biomarkers are also lacking in clinical trials.

Key words: spinal cord injury, metabolomics, biomarkers, review

中图分类号:

R651.2

杨新乐, 王明, 杨成伟, 徐雅洁, 甄平. 脊髓损伤的代谢组学研究进展[J]. 《中国康复理论与实践》, 2018, 24(8): 904-908.

YANG Xin-le, WANG Ming, YANG Cheng-wei, XU Ya-jie, ZHEN Ping. Advance in Metabolomics of Spinal Cord Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(8): 904-908.

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脊髓损伤的代谢组学研究进展

Advance in Metabolomics of Spinal Cord Injury (review)

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