白细胞介素6在中枢神经系统中的研究进展

doi:10.3969/j.issn.1006-9771.2019.05.007

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (5): 540-545.doi: 10.3969/j.issn.1006-9771.2019.05.007

白细胞介素6在中枢神经系统中的研究进展

刘秋燕, 张雷红, 于晓明, 苑爱云

青岛市妇女儿童医院神经康复科，山东青岛市 266034

收稿日期:2018-11-16 修回日期:2018-12-20 出版日期:2019-05-25 发布日期:2019-05-29
通讯作者: 苑爱云(1979-)，女，汉族，山东安丘市人，博士，副主任医师，主要研究方向：神经康复。E-mail: yay79429@126.com
作者简介:刘秋燕(1986-)，女，汉族，山东淄博市人，硕士，医师，主要研究方向：神经康复。
基金资助:
1.山东省医药卫生科技发展计划项目(No. 2015WS0352)；2.青岛市医药科研指导计划项目(No. 2016-WJZD084)；3.青岛市医疗卫生优秀人才培养项目(No. 2017.1-2019.12)

Advance in Interleukin-6 in Central Nervous System (review)

LIU Qiu-yan, ZHANG Lei-hong, YU Xiao-ming, YUAN Ai-yun

Department of Neurological Rehabilitation, Qingdao Women and Children’s Hospital, Qingdao, Shandong 266034, China

Received:2018-11-16 Revised:2018-12-20 Published:2019-05-25 Online:2019-05-29
Contact: YUAN Ai-yun, E-mail: yay79429@126.com
Supported by:
Projects of Medical and Health Technology Development Program in Shandong Province (No. 2015WS0352), the Projects of Medical Science Guidance Program in Qingdao City (No. 2016-WJZD084) and the Qingdao Outstanding Health Professional Development Fund (No. 2017.1-2019.12).

摘要/Abstract

摘要： 中枢神经系统可产生包括白细胞介素6在内的多种神经免疫因子。本文综述白细胞介素6及其受体在中枢神经系统中的表达和信号传导途径以及白细胞介素6在中枢神经系统相关疾病、认知行为学和突触功能调控中的研究进展，提示白细胞介素6作为一种信号分子，参与中枢神经系统的各种生理或病理功能，有望成为某种特定中枢神经系统状态的生物学标记物。

关键词: 白细胞介素6, 神经, 突触, 认知, 综述

Abstract: The central nervous system can produce a variety of neuroimmune factors including interleukin-6. This article reviewed the expression and signaling pathways of interleukin-6 and its receptors in the central nervous system, and advances in interleukin-6 in the regulation of central nervous system related diseases, cognitive behaviors and synaptic function, which suggested that interleukin-6 involves in various physiological or pathological functions in the central nervous system and affects central nervous system in multiple layers such as protein expression, signal transduction, neurological function, and synaptic transmission. Interleukin-6 is expected to be a biological marker in the specific state of the central nervous system. In addition, interleukin-6 can regulate the function of neurons and synapses and is an important molecule involved in synaptic transmission, synaptic plasticity, and learning and memory. Strengthening the research on the biological function and mechanism of interleukin-6 and timely regulating the interleukin-6 expression will provide a new perspective for the treatment of the central nervous system related diseases.

Key words: interleukin-6, nerve, synapse, cognition, review

中图分类号:

R741

刘秋燕, 张雷红, 于晓明, 苑爱云. 白细胞介素6在中枢神经系统中的研究进展[J]. 《中国康复理论与实践》, 2019, 25(5): 540-545.

LIU Qiu-yan, ZHANG Lei-hong, YU Xiao-ming, YUAN Ai-yun. Advance in Interleukin-6 in Central Nervous System (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(5): 540-545.

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白细胞介素6在中枢神经系统中的研究进展

Advance in Interleukin-6 in Central Nervous System (review)

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