Wnt信号通路在周围神经损伤后骨质疏松中的研究进展

doi:10.3969/j.issn.1006-9771.2020.08.011

摘要/Abstract

摘要：

Wnt信号通路对骨代谢具有重要的调节作用。由机械负荷介导的Wnt信号通路抑制剂以及与周围神经系统密切相关的神经生长因子和神经肽(神经肽物质P和神经肽Y)都可以通过Wnt信号通路影响骨代谢。本文从这两个方面就Wnt信号通路在周围神经损伤后骨质疏松中的作用机制进行综述。

关键词: Wnt信号通路, 周围神经损伤, 骨质疏松, 机械负荷, 综述

Abstract:

Wnt signaling pathway plays an important role in bone metabolism. Wnt signaling pathway inhibitors are mediated by the mechanical load, while nerve growth factors and neuropeptide (neuropeptide substance P and neuropeptide Y), which are closely related to the peripheral nervous system, affect bone metabolism through the Wnt signaling pathway. This paper reviewed the mechanism of Wnt signaling pathway in osteoporosis after peripheral nerve injury from these two aspects.

Key words: Wnt signaling pathway, peripheral nerve injury, osteoporosis, mechanical load, review

中图分类号:

R745

王琰,王艳. Wnt信号通路在周围神经损伤后骨质疏松中的研究进展[J]. 《中国康复理论与实践》, 2020, 26(8): 930-935.

WANG Yan,WANG Yan. Advances of Wnt Signaling Pathway in Osteoporosis after Peripheral Nerve Injuries (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(8): 930-935.

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